SAB2900692
Anti-NTSR1 antibody produced in rabbit
affinity isolated antibody
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Synonym(s):
NT-1r, NT1 receptor, NTR, NTS1, NTSR1, Neurotensin receptor type 1
UNSPSC Code:
12352203
NACRES:
NA.41
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry: 6 μg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NTSR1(4923)
General description
The neurotensin receptor 1 (NTSR1) gene has 4 exons and 3 introns and is 53.93 Kb long. NTSR1 is a member of the G protein-coupled receptor (GPCR) family. It consists of 4 extracellular and intracellular loops. It is expressed in the amygdal nucleus, ventral tegmental area, substantia nigra, striatum and entorhinal, and prefrontal cortices of the central nervous system.
Immunogen
Synthetic 18 amino acid peptide from N-terminal extracellular domain of human NTSR1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Elephant (94%); Marmoset (89%); Hamster (83%).
Application
Anti-NTSR1 antibody produced in rabbit has been used in immunohistochemistry (IHC) (1:500).
Biochem/physiol Actions
The neurotensin receptor 1 (NTSR1) plays a regulatory role in the initiation, proliferation, apoptosis, metastasis, and differentiation of tumors through several pathways. Overexpression of NTSR1 is seen in lung cancer, malignant prostatic tumors, and malignant cell lines. NTSR1 is a risk factor that participates in the progression of ductal breast cancer.
Features and Benefits
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Physical form
Solution in phosphate-buffered saline containing less than 0.1% sodium azide.
Supplied at 1 mg/ml
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Ankit Mishra et al.
Drug and chemical toxicology, 1-12 (2021-08-03)
The interaction between neuroendocrine and immune components of the gut maintains the organism's physical and psychological health. Its disruption may reflect in disease conditions such as inflammatory bowel disease (IBD) and mental illness. The lipopolysaccharide (LPS) disrupts the endocrine-immune homeostasis
NTSR1 (neurotensin receptor 1 (high affinity))
Saada S, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2014)
Huan-rong Hu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 40(13), 2524-2536 (2015-12-25)
As a neuropeptide, neurotensin (NTS) is widely expressed in central and peripheral nervous system, which is mainly mediated byneurotensin receptor1 (NTSR1) to activate the related downstream signaling pathways. After summarized the function and mechanism of NTS/NTSR1 in various malignant tumors
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