SAB2702364
Monoclonal Anti-Iba1 antibody produced in mouse
clone GT10312, affinity isolated antibody
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All Photos(5)
Synonym(s):
AIF-1, IBA1, IRT-1, IRT1
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
GT10312, monoclonal
form
buffered aqueous solution
mol wt
17kDa
species reactivity
mouse, human, rat
concentration
2.03mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:1000
indirect immunofluorescence: suitable
western blot: 500-3000
isotype
IgG1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... AIF1(199)
General description
Ionized calcium-binding adapter molecule 1 (IBA1), also called the allograft inflammatory factor 1 (AIF1) is mapped to human chromosome 6p21.33. It encodes a 17 kDa protein and comprises calcium binding EF hand motif. IBA1 is expressed in lung, tonsil, lymph node and spleen. In addition,it is also expressed in macrophages and glial cells.
Immunogen
Recombinant protein encompassing a sequence within the center region of human Iba1.
Application
Monoclonal Anti-Iba1 antibody produced in mouse has been used:
- in the double immunofluorescence
- in the immunofluorescence
- in immunohistochemistry
Biochem/physiol Actions
Ionized calcium-binding adapter molecule 1 (IBA1) interacts with filamentous actin (F‐actin) and L‐fimbrin. Its expression is modulated during injury. Inflammatory cytokines also induce IBA1 expression. IBA1 expression is implicated in the graft rejection in coronary artery vasculopathy (CAV). It is highly expressed in hepatocellular carcinoma and may serve a potential marker and therapeutic target. Increased expression of AIF1 in synovial fluid and peripheral blood monocytes is implicated in rheumatoid arthritis.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Other Notes
Purification: Affinity purified by Protein G
Physical form
Phosphate-buffered saline, no preservative added.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
recommended
Product No.
Description
Pricing
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Treadmill exercise decreases Abeta deposition and counteracts cognitive decline in APP/PS1 mice, possibly via hippocampal microglia modifications
Zhang X, et al.
Frontiers in Aging Neuroscience, 11, 78-78 (2019)
Xianliang Zhang et al.
Frontiers in aging neuroscience, 11, 78-78 (2019-04-27)
Recent studies have suggested that exercise may be beneficial for delaying or attenuating Alzheimer's disease (AD). However, the underlying mechanisms were not clear. Microglia-mediated neuroinflammation is suggested to play an important role in the pathology of AD. The present study
Structural and functional characterization of human Iba proteins
Schulze JO, et al.
The FEBS journal, 275(18), 4627-4640 (2008)
Expression of allograft inflammatory factor-1 in peripheral blood monocytes and synovial membranes in patients with rheumatoid arthritis
Pawlik A, et al.
Human immunology, 77(1), 131-136 (2016)
Repeated injections of human umbilical cord blood-derived mesenchymal stem cells significantly promotes functional recovery in rabbits with spinal cord injury of two noncontinuous segments
Yang C, et al.
Stem Cell Research & Therapy, 9(1), 136-136 (2018)
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