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SAB2702316

Sigma-Aldrich

Monoclonal Anti-CEP152 antibody produced in mouse

clone GT1315, affinity isolated antibody

Synonym(s):

MCPH4, MCPH9, SCKL5

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

GT1315, monoclonal

form

buffered aqueous solution

mol wt

189kDa

species reactivity

human

concentration

1mg/mL

technique(s)

western blot: 1:500-1:3000

isotype

IgG1

UniProt accession no.

O94986

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CEP152(22995)

Related Categories

General description

CEP152 (centrosomal protein 152), a mammalian ortholog of Drosphila asterless is a component of mammalian centrosomes. It is located on human chromosome 15.

Immunogen

Recombinant protein encompassing a sequence within the N-terminus region of human CEP152.

Application

Suggested starting dilutions are as follows: WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Biochem/physiol Actions

This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq]
CEP152 (centrosomal protein 152) plays an important role in cell division and development. It is highly essential for the recruitment of centriole of Plk4 (polo-like kinase 4) and centriole duplication at the time of cell cycle.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Other Notes

Purification: Affinity purified by Protein G

Physical form

Phosphate-buffered saline, no preservative added.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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Primary autosomal recessive microcephaly: homozygosity mapping of MCPH4 to chromosome 15.
Jamieson CR, et al.
American Journal of Human Genetics, 65(5), 1465?1469-1465?1469 (1999)
Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4.
Guernsey DL, et al.
American Journal of Human Genetics, 87(1), 40-51 (2010)
Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication.
Sonnen KF, et al.
Journal of Cell Science, 126(14), 3223-3233 (2013)

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