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SAB2702266

Sigma-Aldrich

Monoclonal Anti-Influenza A virus H1N1 HA (Hemagglutinin) antibody produced in mouse

clone GT223, affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

GT223, monoclonal

form

buffered aqueous solution

species reactivity

influenza A virus

concentration

1mg/mL

technique(s)

indirect immunofluorescence: suitable
western blot: 500-3000

isotype

IgG1

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Related Categories

General description

Influenza virus hemagglutinin (HA) precursor is encoded by the gene mapped on segment 4. The encoded protein is a 76kDa surface glycoprotein and it exists as trimers on the envelope.

Immunogen

Recombinant fragment corresponding to C-terminal region of Influenza A virus Hemagglutinin (HA) (A/WSN/1933(H1N1)).

Application

Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Biochem/physiol Actions

Influenza virus hemagglutinin (HA) acts as a key immunogen in avian influenza virus (AIV) vaccines. Activated HA facilitates virus attachment to oligosaccharide receptors on host cell surface and is involved in penetration through fusion following conformational modifications in the endolysosomal compartment. 226 and 228 residues in HA of the H3 subtype play a key role in host range restriction and receptor specificity.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Other Notes

Purification: Affinity purified by Protein G

Physical form

Phosphate-buffered saline, no preservative added.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity.
Glaser L
Journal of Virology (2005)
The role of influenza A virus hemagglutinin residues 226 and 228 in receptor specificity and host range restriction.
Vines A
Journal of Virology (1998)
Barbara Szutkowska et al.
International journal of molecular sciences, 23(5) (2022-03-11)
Influenza A virus (IAV) is a member of the single-stranded RNA (ssRNA) family of viruses. The most recent global pandemic caused by the SARS-CoV-2 virus has shown the major threat that RNA viruses can pose to humanity. In comparison, influenza

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