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SAB2702149

Sigma-Aldrich

Monoclonal Anti-SAFB antibody produced in mouse

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Synonym(s):
HAP, HET, SAF-B1, SAFB1
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

6F7
monoclonal

form

liquid

mol wt

102 kDa

species reactivity

mouse, human

concentration

1 mg/mL

technique(s)

immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

isotype

IgG1

UniProt accession no.

Q15424

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SAFB(6294)

Immunogen

A synthetic peptide corresponding to amino acids 345-357 (PEARDSKEDGRKF) of the human HET protein.

Application

For ICC/IF: Use at an assay dependent dilution. For IP: Use at an assay dependent dilution. For WB: Use at a concentration of 1 - 2 μg/mL. Optimal dilutions/concentrations should be determined by the researcher.

Biochem/physiol Actions

Hsp27 ERE-TATA binding protein (HET)/ Scaffold Attachment Factor-B (SAF-B) is a member of a subset of nuclear matrix proteins that mediate the attachment of chromatin to nuclear protein complexes. The calculated molecular weight of HET/SAF-B is 102 kDa (Accession No. U72355), but on SDS PAGE gels HET/SAF-B runs as an approximately 130 kDa protein. This aberrant migration is due to a large number of charged amino acid residues.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Phosphate-buffered saline, no preservative added.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Chrysa Taze et al.
Redox biology, 58, 102545-102545 (2022-11-26)
The cellular response to hypoxia, in addition to HIF-dependent transcriptional reprogramming, also involves less characterized transcription-independent processes, such as alternative splicing of the VEGFA transcript leading to the production of the proangiogenic VEGF form. We now show that this event

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