SAB2702133
Monoclonal Anti-CEP164 antibody produced in mouse
Synonym(s):
Cep164 Antibody, Cep164 Antibody - Monoclonal Anti-CEP164 antibody produced in mouse, NPHP15
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
13
monoclonal
form
liquid
species reactivity
human
concentration
1 mg/mL
technique(s)
immunocytochemistry: suitable
immunofluorescence: suitable
immunoprecipitation (IP): suitable
western blot: 1:500-1:3000
isotype
IgG1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CEP164(22897)
General description
The centrosomal protein 164 (CEP164) is expressed at the distal ends of the mother centriole. This protein consists of an N-terminal WW domain and three coiled-coil regions. The CEP164 gene is located on the human chromosome at 11q23.3.
Immunogen
Human Cep164
Application
Monoclonal Anti-CEP164 antibody produced in mouse has been used in immunoblotting (5 μg/ml).
Biochem/physiol Actions
The centrosomal protein 164 (CEP164) plays an important role in the synthesis of the primary cilium. This protein interacts with several proteins during ciliogenesis such as Rabin-8, Tau tubulin kinase‐2 (TTBK2), coiled-coil domain containing 41 (CCDC41), and dishevelled (DVL). CEP164 protein is also involved in G2/M checkpoint and nuclear divisions. This protein is a key player in the DNA damage-activated ataxia telangiectasia mutated (ATM)/Rad3-related (ATR) signaling cascade since it is required for the proper phosphorylation of the histone family member X (H2AX), replication protein A (RPA), checkpoint kinase 1 and 2 (CHK1/2). Mutations in the CEP164 gene leads to a condition known as nephronophthisis (NPHP)‐related ciliopathies.
Features and Benefits
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Physical form
Phosphate-buffered saline, no preservative added.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Toshiaki Oda et al.
Genes to cells : devoted to molecular & cellular mechanisms, 19(12), 927-940 (2014-10-10)
Primary cilia are formed by extending the microtubule-based axoneme from the mother centriole-derived basal body. Recruitment of Tau tubulin kinase-2 (TTBK2) to the mother centriole and subsequent removal of CP110 and its interactor Cep97 are crucial for the initiation of
Susanne Graser et al.
The Journal of cell biology, 179(2), 321-330 (2007-10-24)
Primary cilia (PC) function as microtubule-based sensory antennae projecting from the surface of many eukaryotic cells. They play important roles in mechano- and chemosensory perception and their dysfunction is implicated in developmental disorders and severe diseases. The basal body that
Sudhakar Sivasubramaniam et al.
Genes & development, 22(5), 587-600 (2008-02-20)
The activation of the ataxia telangiectasia mutated (ATM) and ATM/Rad3-related (ATR) kinases triggers a diverse cellular response including the initiation of DNA damage-induced cell cycle checkpoints. Mediator of DNA Damage Checkpoint protein, MDC1, and H2AX are chromatin remodeling factors required
Rebecca V Walker et al.
Nature communications, 10(1), 4072-4072 (2019-09-08)
The human PKD2 locus encodes Polycystin-2 (PC2), a TRPP channel that localises to several distinct cellular compartments, including the cilium. PKD2 mutations cause Autosomal Dominant Polycystic Kidney Disease (ADPKD) and affect many cellular pathways. Data underlining the importance of ciliary
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