SAB2701974
Anti-SOX2 antibody produced in rabbit
Synonym(s):
ANOP3, MCOPS3
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All Photos(20)
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
liquid
mol wt
34 kDa
species reactivity
mouse, human, rat
concentration
1 mg/mL
technique(s)
flow cytometry: 50-200
immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 500-20000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... SOX2(6657)
Related Categories
General description
SOX2 (sex-determining region Y-box 2) is a transcription factor that is made of 317 amino acids. It has a HMG (high mobility group box) domain and is a critical transcription regulator of normal stem cells. This gene is located on human chromosome 3q26.3.
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 291 of SOX2 (Uniprot ID#P48431)
Application
Suggested starting dilutions are as follows: FACS: 1:50-1:200, ICC/IF: 1:100-1:1000, IHC-Fr: 1:100-1:1000, IHC-P: 1:100-1:1000, IP: 1:100-1:500, WB: 1:500-1:20000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Biochem/physiol Actions
SOX2 (sex-determining region Y-box 2) down-regulation reduces the stem cell count, that affects the breast cancer cells in initiating tumor progression. It participates in chemoresistance and regular lung cancer therapies. In mouse, SOX2 plays an important role in branching morphogenesis and regulating lung epithelial cell differentiation.
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq]
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 3 - Skin Sens. 1
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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An Beckers et al.
Neuroscience, 470, 52-69 (2021-07-20)
Optic neuropathies comprise a group of disorders in which the axons of retinal ganglion cells (RGCs), the retinal projection neurons conveying visual information to the brain, are damaged. This results in visual impairment or even blindness, which is irreversible as
SOX2 Is an Oncogene Activated by Recurrent 3q26.3 Amplifications in Human Lung Squamous Cell Carcinomas
Hussenet T, et al.
PLoS ONE (2010)
Emi Inada et al.
Biological procedures online, 23(1), 12-12 (2021-06-13)
Expression of stemness factors, such as octamer-binding transcription factor 3/4 (OCT3/4), sex determining region Y-box 2 (SOX2), and alkaline phosphatase (ALP) in human deciduous tooth-derived dental pulp cells (HDDPCs) can be assessed through fixation and subsequent immuno- or cytochemical staining.
Sox2 inhibits Wnt-?-catenin signaling and metastatic potency of cisplatin-resistant lung adenocarcinoma cells
He J, et al.
Molecular Medicine Reports, 15(4), 1693-1701 (2017)
Nikita S Sharma et al.
Theranostics, 9(12), 3410-3424 (2019-07-10)
Pancreatic adenocarcinoma (PDAC) claims more than 90% of the patients diagnosed with the disease owing to its aggressive biology that is manifested by high rate of tumor recurrence. Aberrant upregulation in the transcriptional activity of proteins involved in self-renewal like
Articles
Frequently asked questions about neural stem cells including NSC derivation, expansion and differentiation.
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