SAB2701049
Anti-CDT1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
CDT1, DUP, RIS2
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry: suitable
indirect immunofluorescence: suitable
western blot: 500-3000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CDT1(81620)
General description
Chromatin licensing and DNA replication factor 1/Cdc10-dependent transcript 1 (CDT1), a G1-specific cell-cycle factor, belongs to the pre-replication complex (pre-RC). The CDT1 gene is located on the human chromosome 16q24.3.
Immunogen
Synthetic peptide containing a sequence corresponding to a region within amino acids 448 and 490 (Q9H211) of CDT1 according to AAH08676
Application
Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-P: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Biochem/physiol Actions
Chromatin licensing and DNA replication factor 1/Cdc10-dependent transcript 1 (CDT1) is involved in minichromosome maintenance (MCM) loading at the G1 phase of the cell cycle. It plays a key role in origin licensing in eukaryotic cells. It is a DNA replication protein that stimulates the production of pre-replicative complexes and replication in the next cell cycle by accumulating at the end of the cell cycle. The CDT1 gene mutation can cause Meier–Gorlin syndrome, a type of primordial dwarfism.
Features and Benefits
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Physical form
1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 3 - Skin Sens. 1
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Cdt1 interactions in the licensing process: a model for dynamic spatiotemporal control of licensing.
Georgia Xouri et al.
Cell cycle (Georgetown, Tex.), 6(13), 1549-1552 (2007-06-30)
Within each cell cycle, a cell must ensure that the processes of selection of replication origins (licensing) and initiation of DNA replication are well coordinated to prevent reinitiation of DNA replication from the same DNA segment during the same cell
Andrea Ballabeni et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(30), E2848-E2853 (2013-07-10)
Cdc10-dependent transcript 1 (Cdt1) is an essential DNA replication protein whose accumulation at the end of the cell cycle promotes the formation of pre-replicative complexes and replication in the next cell cycle. Geminin is thought to be involved in licensing
Vassilis Roukos et al.
Journal of cell science, 124(Pt 3), 422-434 (2011-01-13)
For genomic integrity to be maintained, the cell cycle and DNA damage responses must be linked. Cdt1, a G1-specific cell-cycle factor, is targeted for proteolysis by the Cul4-Ddb1(Cdt2) ubiquitin ligase following DNA damage. Using a laser nanosurgery microscope to generate
Hui-Hui Xie et al.
Medicine, 100(7), e24382-e24382 (2021-02-21)
Subchromosomal deletions and duplications could currently be detected by noninvasive preliminary screening (NIPS). However, NIPS is a screening test that requires further diagnosis. Here we report a fetus with an autosomal abnormality revealed by NIPS and conventional karyotype combined with
Pedro N Pozo et al.
Molecular biology of the cell, mbcE18040242-mbcE18040242 (2018-10-04)
The earliest step in DNA replication is origin licensing which is the DNA loading of MCM helicase complexes. The Cdt1 protein is essential for MCM loading during G1 phase of the cell cycle, yet the mechanism of Cdt1 function is
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