SAB2502028
Anti-SLC6A4 (C-terminal) antibody produced in goat
affinity isolated antibody, buffered aqueous solution
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Synonym(s):
5-HTT, 5-HTTLPR, 5HTT, HTT, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, bovine, human, mouse
technique(s)
ELISA: suitable
flow cytometry: suitable
immunofluorescence: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SLC6A4(6532)
Related Categories
General description
Solute carrier family 6 member 4 (SLC6A4) is also known as 5-hydroxytryptamine transporter (5-HTT). It is an integral membrane protein, which is mapped to human chromosome 17q11.2. The encoded protein is a member of the SLC6 (solute carrier family 6) gene family and is mainly expressed in brain and blood cells.
Immunogen
Peptide with sequence C-KERIIKSITPETPT, from the C-terminal region of the protein sequence according to NP_001036.1
Biochem/physiol Actions
Solute carrier family 6 member 4 (SLC6A4) catalyzes the transport of neurotransmitter serotonin from the synaptic space into presynaptic neurons. It plays a vital role in mood and anxiety regulation. Mutation in the gene may alter the expression of serotonin (5HT) in the synaptic cleft, which ultimately leads to schizophrenia. Allelic variations in the gene increase the risk of susceptibility to autism and rigid-compulsive behaviors.
Features and Benefits
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Physical form
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
含少量动物源组分生物产品
常规特殊物品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Linkage mapping of serotonin transporter protein gene SLC6A4 on chromosome 17
J Gelernter, et al.
Human Genetics, 95(6), 677-680 (1995)
The solute carrier 6 family of transporters
S Broer, et al.
British Journal of Pharmacology, 167(2), 256-278 (2012)
Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets
B D Greenberg, et al.
American Journal of Medical Genetics, 88(1), 83-87 (1999)
Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors
J S Sutcliffe, et al.
American Journal of Human Genetics, 77(2), 265-279 (2005)
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