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Merck
CN

S0193

SKF-86002

≥98% (HPLC), solid

Synonym(s):

6-(4-Fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole

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About This Item

Empirical Formula (Hill Notation):
C16H12N3FS
CAS Number:
72873-74-6
Molecular Weight:
297.35
NACRES:
NA.77
PubChem Substance ID:
24724598
UNSPSC Code:
12352200
MDL number:
MFCD00869367
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
protect from light

Key Documents

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Product Name

SKF-86002, ≥98% (HPLC), solid

InChI

1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2

SMILES string

Fc1ccc(cc1)-c2nc3SCCn3c2-c4ccncc4

InChI key

YOELZIQOLWZLQC-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

off-white

mp

189-190 °C (lit.)

solubility

DMSO: soluble >10 mg/mL

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... IL1B(3553), TNF(7124)
rat ... Alox5(25290)

Related Categories

Biochem/physiol Actions

p38 MAP kinase inhibitor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
127K46111
127K4611
086K46091
086K4609
043K4603

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B Schnyder et al.
The Biochemical journal, 331 ( Pt 2), 489-495 (1998-06-11)
Intracellular phosphorylations polymorphonuclear neutrophils are mediated by kinases, including mitogen activated-protein (MAP) kinases and phosphatidylinositol 3-kinase. In the present study we demonstrate their effector functions upon both ligation of cell-surface seven-transmembrane-spanning receptors by bacterial peptide formylmethionyl-leucylphenylalanine as well as in
Javier Hernández Losa et al.
Oncogene, 22(26), 3998-4006 (2003-06-25)
p38 MAPK has been implicated in the response to cancer therapy. To determine whether the activation of p38 MAPK could be specific to cancer therapy, we investigated the activation of p38 MAPK in response to several chemotherapeutic agents, such as
David J Diller et al.
Current topics in medicinal chemistry, 5(10), 953-965 (2005-09-24)
In the late 1970s and the early 1980s the initial p38 chemotype, the triaryl imidazoles, was discovered as an off-target effect during the development of cyclooxygenase and 5-lipoxygenase inhibitors long before the identity of the p38 kinase was known. During
Donna E Muscarella et al.
Toxicological sciences : an official journal of the Society of Toxicology, 68(1), 82-92 (2002-06-21)
Various forms of inorganic arsenic are significant environmental contaminants that have multiple effects on cells, including the induction of apoptotic cell death. Induction of apoptosis in lymphoid cells can mediate immunotoxicity following exposure to chemicals. However, the mechanisms regulating the
A Sodhi et al.
Cancer research, 60(17), 4873-4880 (2000-09-15)
The elucidation of the molecular mechanisms governing the transition from a nonangiogenic to an angiogenic phenotype is central for understanding and controlling malignancies. Viral oncogenes represent powerful tools for disclosing transforming mechanisms, and they may also afford the possibility of
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