Skip to Content

Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

Merck
CN
All Photos(3)

Key Documents

View All Documentation

Q4951

Sigma-Aldrich

Quercetin

≥95% (HPLC), solid, flavonoid antioxidant

Synonym(s):

2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one, 3,3′,4′,5,6-Pentahydroxyflavone

Sign Into View Organizational & Contract Pricing

Select a Size

100 ML
CN¥528.15

CN¥528.15

Available to ship onApril 25, 2025Details

Request a Bulk Order
All Photos(3)

Select a Size

Change View
100 ML
CN¥528.15

About This Item

Empirical Formula (Hill Notation):
C15H10O7
CAS Number:
117-39-5
Molecular Weight:
302.24
Beilstein:
317313
EC Number:
204-187-1
UNSPSC Code:
12352207
PubChem Substance ID:
329823865
NACRES:
NA.77

CN¥528.15

Available to ship onApril 25, 2025Details

Request a Bulk Order

Product Name

Quercetin, ≥95% (HPLC), solid

biological source

synthetic (organic)

Quality Level

200

Assay

≥95% (HPLC)

form

solid

mp

316.5 °C

solubility

water: practically insoluble

storage temp.

room temp

SMILES string

OC1=CC(O)=C2C(OC(C3=CC=C(O)C(O)=C3)=C(O)C2=O)=C1

InChI

1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
489004437843925
Calcofluor White Stain suitable for microbiology

18909

Calcofluor White Stain

Giemsa Stain, Modified Solution (for the staining (of cellular blood components and blood parasites))

48900

Giemsa Stain, Modified Solution

M’Fadyean Stain Solution suitable for microbiology

44378

M′Fadyean Stain Solution

Nigrosin Stain solution suitable for microscopy

43925

Nigrosin Stain solution

technique(s)

microbe id | staining: suitable

technique(s)

microbe id | staining: suitable

technique(s)

microbe id | staining: suitable

technique(s)

microbe id | staining: suitable

suitability

fungi, yeasts, parasites

suitability

Chlamydia spp., Histoplasma spp., Plasmodium spp., Trichomonas spp., bacteria, protozoa, spirochetes

suitability

Bacillus spp., Corynebacterium spp.

suitability

Bacillus spp., Corynebacterium spp.

fluorescence

λex 423-443 nm in 0.1 M phosphate pH 7.0

fluorescence

-

fluorescence

-

fluorescence

-

color

blue to very dark blue

color

-

color

-

color

-

form

liquid

form

-

form

liquid

form

liquid

application(s)

food and beverages
hematology
histology, microbiology

application(s)

-

application(s)

diagnostic assay manufacturing
hematology
histology, microbiology

application(s)

diagnostic assay manufacturing
hematology
histology

General description

Quercetin is a polyphenolic flavonoid, found in food including onions, asparagus, buckwheat, radish leaves, green tea, cranberry, broccoli, apple, blueberry, and coriander. Quercetin shows strong intramolecular H-binding, which contributes to the bioavailability and transport of the compound. This explains the biological multi-functional nature of the compound and allows for the formation of strong complexes, frequently with metals.[1] Quercetin inhibits cellular proliferation and minimizes DNA damage. Among its many cardiovascular protection properties, quercetin has antioxidant and antiplatelet properties as well as antiplatelet and anti-muscle cell proliferation and migration. It also enhances cardiac cell mitochondrial function and inhibits NF-κB. Numerous animal studies involving dietary quercetin supplementation have shown a protective effect against cardiac problems.[2]

Application

  • Quercetin has been used as an antioxidant which reversed the immunosuppressive effects of high glucose and hyperglycemic sera in type 2 diabetic patients.[3]
  • It has been used as a detoxifying phytochemical in Apis mellifera.[4]
  • It has been used as a positive control in DPPH (2,2- diphenyl-1-picryhydrazyl) radical scavenging assay. It has also been used for the preparation of calibration curve to determine total flavonoid content.[5]

Biochem/physiol Actions

Quercetin is a flavonoid with anticancer activity. Quercetin is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle. Quercetin may also inhibit fatty acid synthase activity.
Quercetin is a flavonoid with anticancer activity. Quercetin is a mitochondrial ATPase and phosphodiesterase inhibitor. It inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin may also inhibit fatty acid synthase activity.

Features and Benefits

This compound is a featured product for ADME Tox and Kinase Phosphatase research. Discover more featured ADME Tox and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

This chemical is soluble in DMSO (30 mg/ml), DMF (~30 mg/ml), and ethanol (~2 mg/ml).

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    0000435915
    0000435915
    0000431865
    0000431865
    0000433295

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Search for a COA

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    High glucose and hyperglycemic sera from type 2 diabetic patients impair DC differentiation by inducing ROS and activating Wnt/?-catenin and p38 MAPK.
    Gilardini Montani MS et al.
    Biochimica et Biophysica Acta, 1862, 805-805 (2016)
    Lucia Panzella et al.
    Antioxidants (Basel, Switzerland), 8(4) (2019-04-04)
    Exhausted woods represent a byproduct of tannin industrial production processes and their possible exploitation as a source of antioxidant compounds has remained virtually unexplored. We herein report the characterization of the antioxidant and other properties of practical interest of exhausted
    Joanna Cunanan et al.
    PloS one, 15(6), e0234375-e0234375 (2020-06-20)
    Renal dysplasia, the major cause of childhood renal failure, is characterized by defective branching morphogenesis and nephrogenesis. Beta-catenin, a transcription factor and cell adhesion molecule, is markedly increased in the nucleus of kidney cells in human renal dysplasia and contributes
    Impacts of Dietary Phytochemicals in the Presence and Absence of Pesticides on Longevity of Honey Bees (Apis mellifera).
    Liao LH et al.
    Insects, 8, E22-E22 (2017)
    Phenolic and flavonoid content and antioxidants capacity of pressurized liquid extraction and perculation method from roots of Scutellaria pinnatifida A. Hamilt. subsp alpina (Bornm) Rech. f.
    Golmakani E et al.
    Journal of Supercritical Fluids, 95, 318-324 (2014)
    View All Related Papers

    Articles

    Fatty Acid Synthesis in Cancer Cells

    Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.

    Discover Bioactive Small Molecules for Kinase Phosphatase Biology

    Discover Bioactive Small Molecules for Kinase Phosphatase Biology

    Discover Bioactive Small Molecules for ADME/Tox

    Discover Bioactive Small Molecules for ADME/Tox

    Discover Bioactive Small Molecules for Lipid Signaling Research

    Discover Bioactive Small Molecules for Lipid Signaling Research

    Protocols

    HPLC Analysis of Flavonoids on Ascentis® RP-Amide

    Protocol for HPLC Analysis of Flavonoids on Ascentis® RP-Amide

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service