Q2128
Quisqualic acid
L-glutamate agonist, powder
Synonym(s):
β-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine, 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine
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About This Item
Empirical Formula (Hill Notation):
C5H7N3O5
CAS Number:
Molecular Weight:
189.13
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Beilstein/REAXYS Number:
1078734
Product Name
Quisqualic acid, powder
form
powder
Quality Level
color
white to off-white
solubility
ethanol: <0.17 mg/mL, H2O: 0.5 mg/mL, 0.1 M HCl: 1.4 mg/mL, 1 M NH4OH: 20 mg/mL, organic solvents: insoluble
storage temp.
2-8°C
SMILES string
N[C@@H](CN1OC(=O)NC1=O)C(O)=O
InChI
1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
InChI key
ASNFTDCKZKHJSW-REOHCLBHSA-N
Gene Information
General description
Quisqualate/ Quisqualic acid is obtained from the fruits and seeds of Quisqualis chinensis. It is an agonist at two subsets of excitatory amino acid receptors metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores and, ionotropic receptors that directly control membrane channels. L-quisqualic acid is an agonist of the neurotransmitter L-glutamate.
Application
Quisqualic acid has also been used as a group I metabotropic receptor agonist in neurons.
Quisqualic acid has been used to test ligand-gated receptors in spiral ganglion neurons.
Biochem/physiol Actions
Active enantiomer of quisqualic acid; excitatory amino acid at glutamate receptors.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Pablo J Giraudi et al.
PloS one, 6(12), e29078-e29078 (2012-01-05)
We have previously reported that exposure of SH-SY5Y neuroblastoma cells to unconjugated bilirubin (UCB) resulted in a marked up-regulation of the mRNA encoding for the Na(+)-independent cystine∶glutamate exchanger System X(c)(-) (SLC7A11 and SLC3A2 genes). In this study we demonstrate that
Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine null
Optical recordings of Ca2+ signaling activities from identified inner ear cells in cochlear slices and hemicochleae
Xi Lin
Brain Res. Protoc., 11(2) (2003)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| Q2128-5MG | 04061833007983 |
| Q2128-25MG | 04061833007976 |
| Q2128-10MG | 04061836687847 |
| Q2128-1MG | 04061826676721 |