P9989
Protein Phosphatase 2A from human erythrocytes
~2000 units/mg enzyme protein, buffered aqueous glycerol solution
Synonym(s):
PP2A human
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About This Item
UNSPSC Code:
12352204
MDL number:
form
buffered aqueous glycerol solution
specific activity
~2000 units/mg enzyme protein
mol wt
~96 kDa
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... PPP2R4(5524)
Biochem/physiol Actions
Protein phosphatase active against phosphorylated Ser/Thr proteins and peptides
Physical form
Approx. 2 U/microgram in 20 mM MOPS, pH 7.5, 150 mM NaCl, 60 mM 2-mercaptoethanol, 1 mM MgCl2, 2 mM EGTA, 0.1 mM ZnCl2, 0.1 mg/ml BSA, 50% glycerol.
Other Notes
One unit will release 1.0 nanomole/min of phosphate from a 15 μM solution of active phosphorylase enzyme
Regulatory Information
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D B DeFranco et al.
Molecular endocrinology (Baltimore, Md.), 5(9), 1215-1228 (1991-09-01)
We have used okadaic acid (OA), a cell-permeable inhibitor of serine/threonine protein phosphatase types 1 (PP-1) and 2A (PP-2A), to demonstrate that the subcellular distribution of glucocorticoid receptor (GR) in rat fibroblasts is influenced by its phosphorylation state. Nuclear GRs
A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation.
A Ito et al.
The EMBO journal, 19(4), 562-571 (2000-02-17)
Both F10 and BL6 sublines of B16 mouse melanoma cells are metastatic after intravenous injection, but only BL6 cells are metastatic after subcutaneous injection. Retrotransposon insertion was found to produce an N-terminally truncated form (Deltagamma1) of the B56gamma1 regulatory subunit
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