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P9989

Sigma-Aldrich

Protein Phosphatase 2A from human erythrocytes

~2000 units/mg enzyme protein, buffered aqueous glycerol solution

Synonym(s):

PP2A human

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About This Item

MDL number:
UNSPSC Code:
12352204

form

buffered aqueous glycerol solution

specific activity

~2000 units/mg enzyme protein

mol wt

~96 kDa

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... PPP2R4(5524)

Biochem/physiol Actions

Protein phosphatase active against phosphorylated Ser/Thr proteins and peptides

Unit Definition

One unit will release 1.0 nanomole/min of phosphate from a 15 μM solution of active phosphorylase enzyme

Physical form

Approx. 2 U/microgram in 20 mM MOPS, pH 7.5, 150 mM NaCl, 60 mM 2-mercaptoethanol, 1 mM MgCl2, 2 mM EGTA, 0.1 mM ZnCl2, 0.1 mg/ml BSA, 50% glycerol.

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A Ito et al.
The EMBO journal, 19(4), 562-571 (2000-02-17)
Both F10 and BL6 sublines of B16 mouse melanoma cells are metastatic after intravenous injection, but only BL6 cells are metastatic after subcutaneous injection. Retrotransposon insertion was found to produce an N-terminally truncated form (Deltagamma1) of the B56gamma1 regulatory subunit
D B DeFranco et al.
Molecular endocrinology (Baltimore, Md.), 5(9), 1215-1228 (1991-09-01)
We have used okadaic acid (OA), a cell-permeable inhibitor of serine/threonine protein phosphatase types 1 (PP-1) and 2A (PP-2A), to demonstrate that the subcellular distribution of glucocorticoid receptor (GR) in rat fibroblasts is influenced by its phosphorylation state. Nuclear GRs

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