P9864
PTP-β human
≥90%, recombinant, expressed in E. coli K12, GST-tagged, buffered aqueous glycerol solution, ≥50,000 units/mg protein
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Synonym(s):
Protein Tyrosine Phosphatase-β
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biological source
human
Quality Level
recombinant
expressed in E. coli K12
Assay
≥90%
form
buffered aqueous glycerol solution
specific activity
≥50,000 units/mg protein
mol wt
~250 kDa
UniProt accession no.
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PTPRB(5787)
General description
Protein tyrosine phosphatase, receptor type B (PTPRB), also known as vascular endothelial-protein-tyrosine phosphatase (VE-PTP), might have a role in remodeling of blood vessels and in angiogenesis. The gene encoding it is localized on human chromosome 12q15. It is also important for endothelial cell migration. The protein also controls the phosphorylation state of the angiopoietin receptor, Tie-2. PTPRB may modulate sodium channels by influencing the tyrosine phosphorylation status.
Biochem/physiol Actions
Dephosphorylates tyrosine proteins.
Unit Definition
One unit of PTP-β will hydrolyze 1.0 nanomole of p-nitrophenyl phosphate per min at 30 °C.
Physical form
solution in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCL, 3 mM DTT, 16 mM glutathione and 20% glycerol
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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INTERNATIONAL CONFERENCE OF COMPUTATIONAL METHODS IN SCIENCES AND ENGINEERING 2009:(ICCMSE 2009). (2016)
1002 protein phosphatases?
H Charbonneau et al.
Annual review of cell biology, 8, 463-493 (1992-01-01)
A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta.
Ratcliffe CF
Nature Neuroscience (2000)
Picomolar concentrations of free zinc(II) ions regulate receptor protein-tyrosine phosphatase ? activity.
Wilson M
The Journal of Biological Chemistry (2012)
Shear stress-induced redistribution of vascular endothelial-protein-tyrosine phosphatase (VE-PTP) in endothelial cells and its role in cell elongation.
Mantilidewi KI
The Journal of Biological Chemistry (2014)
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