P9638
L-α-Phosphatidylinositol 4-monophosphate sodium salt
≥98%
Synonym(s):
1,2-Diacyl-sn-glycero-3-phospho-(1-D-myo-inositol 4-phosphate) sodium-potassium salt, Diphosphoinositide sodium salt, PIP, PtdInsP
assay
≥98%
form
powder
solubility
H2O: soluble
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
Phosphorylated phospholipid membrane component, precursor of inositol phosphates. Formed in brain membranes from phosphatidylinositol by phosphatidylinositol 4-kinase.
Features and Benefits
This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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C A O'Brian et al.
FEBS letters, 214(2), 339-342 (1987-04-20)
Protein kinase C(PKC) is a Ca2+- and phospholipid-dependent protein kinase which can be activated by diacylglycerol, a product of polyphosphoinositide hydrolysis. In this report, we show that the polyphosphoinositides L-alpha-phosphatidylinositol 4-monophosphate (PI 4P) and L-alpha-phosphatidylinositol 4,5-diphosphate (PI 4.5DP) can serve
L Raptis et al.
Journal of virology, 63(2), 753-758 (1989-02-01)
Polyomavirus middle tumor antigen (mT) was expressed in a line of mouse NIH 3T3 cells under control of the dexamethasone-regulatable mouse mammary tumor virus promotor. Contrary to rat F111 cells which were rendered anchorage independent by mT expression alone (L.
Siavash Fazel Darbandi et al.
Cell reports, 31(2), 107495-107495 (2020-04-16)
Tbr1 is a high-confidence autism spectrum disorder (ASD) gene encoding a transcription factor with distinct pre- and postnatal functions. Postnatally, Tbr1 conditional knockout (CKO) mutants and constitutive heterozygotes have immature dendritic spines and reduced synaptic density. Tbr1 regulates expression of
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