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P5057

Sigma-Aldrich

Paromomycin sulfate salt

powder, suitable for cell culture, BioReagent

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Empirical Formula (Hill Notation):
C23H45N5O14 · xH2SO4
CAS Number:
1263-89-4
Molecular Weight:
615.63 (free base basis)
Beilstein:
5715182
UNSPSC Code:
12352207
PubChem Substance ID:
24898585
NACRES:
NA.76

product line

BioReagent

Quality Level

200

form

powder

potency

≥675 μg per mg

technique(s)

cell culture | mammalian: suitable

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

Mode of action

protein synthesis | interferes

SMILES string

O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C

InChI

1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1

InChI key

OYJABWUHUYVDMJ-UDXJMMFXSA-N

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General description

Chemical structure: aminoglycoside
Paromomycin or aminosidine, an aminoglycoside belongs to the class of aminoglycosides. This nonabsorbable antibiotic is found at high level in the lumen of the colon.

Application

  • Paromomycin sulfate salt has been used as a:
  • reference compound in antileishmanial activity
  • RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex.
Recommended for use in cell culture applications at 100mg/L.
Paromomycin sulfate salt has been used as a positive control to compare the purine analog antiviral 2′,3′-dideoxyinosine (ddI).

Biochem/physiol Actions

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.
Paromomycin possesses antileishmanial and antibacterial activities. It is used to cure visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). This aminocyclitol glycoside is active against gram-negative and gram-positive bacteria. It is also active against E. histolytica, D. fragilis and several cestodes, like Taenia saginata, Taenia solium etc.

Other Notes

1g,5g
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Use of a non-adherent cell culture system for testing the effect of 2,3'-dideoxyinosine against Cryptosporidium parvum
Lawton P, et al.
FEMS Microbiology Letters, 176(1), 235-240 (1999)
Paromomycin
Davidson RN, et al.
Transactions of the Royal Society of Tropical Medicine and Hygiene, 103(7), 653-660 (2009)
Antiparasitic Agents
Infectious Diseases, 2, 1345-1372 (2017)
Nanoarchitectures for Neglected Tropical Protozoal Diseases: Challenges and State of the Art
Nano- and Microscale Drug Delivery Systems, 439-480 (2017)
Jair L Siqueira-Neto et al.
PLoS neglected tropical diseases, 4(5), e675-e675 (2010-05-11)
Drugs currently available for leishmaniasis treatment often show parasite resistance, highly toxic side effects and prohibitive costs commonly incompatible with patients from the tropical endemic countries. In this sense, there is an urgent need for new drugs as a treatment
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