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Key Documents

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Safety Information

P4235

Sigma-Aldrich

Anti-p53 antibody produced in sheep

fractionated antiserum, buffered aqueous solution

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4 L
CN¥2,166.96

CN¥2,166.96

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4 L
CN¥2,166.96

About This Item

MDL number:
MFCD00164709
UNSPSC Code:
12352203
NACRES:
NA.41

CN¥2,166.96

Please contact Customer Service for Availability
Request a Bulk Order

biological source

sheep

Quality Level

200

conjugate

unconjugated

antibody form

fractionated antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 53 kDa

species reactivity

rat, mouse, human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
western blot: 1-10 μg/mL

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Phenol red (phenolsulfonphthalein) Reag. Ph Eur

159375

Phenol red

Phenol Red ACS reagent

114529

Phenol Red

Phenol Red powder, BioReagent, suitable for cell culture

P3532

Phenol Red

Phenol Red Meets ACS Specifications GR ACS

PX0530

Phenol Red

form

solid

form

powder

form

powder

form

powder

storage temp.

no temp limit

storage temp.

room temp

storage temp.

room temp

storage temp.

10-30°C

assay

98.0-102.0% (bromatometric, calculated on dried substance)

assay

-

assay

-

assay

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

-

mp

>300 °C

mp

-

mp

>300 °C

mp

>300 °C

agency

reag. Ph. Eur.

agency

-

agency

-

agency

-

General description

p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.

Immunogen

GST fusion protein of human p53 corresponding to amino acids 1-393.

Application

Monoclonal Anti-p53-Biotin antibody produced in mouse has been used for Western Blotting.

Biochem/physiol Actions

Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.

Physical form

Solution in 0.01 M phosphate buffered saline, containing 0.08% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品
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    Certificates of Analysis (COA)

    Lot/Batch Number
    SLBZ6383
    SLBZ4348
    SLBV4188
    SLBR8927V
    SLBP3540V

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    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

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    Cell Cycle and Apoptosis
    Bruna Pucci
    Neoplasia, 2(4) (2000)
    Cell Cycle and Apoptosis
    Bruna Pucci
    Neoplasia, 2(4) (2000)
    ZnO nanorod-induced apoptosis in human alveolar adenocarcinoma cells via p53, survivin and bax/bcl-2 pathways: role of oxidative stress
    Ahamad M
    Nanomedicine: Nanotechnology, Biology, and Medicine, 7, 904-913 (2011)
    Multiple myeloma involving central nervous system: high frequency of chromosome 17p13.1 (p53) deletions
    Hong Chang
    British Journal of Haematology, 127(3), 280?284-280?284 (2004)
    Suppression of p53 potentiates chemosensitivity in nutrient?deprived cholangiocarcinoma cells via inhibition of autophagy
    Fei Hui
    Oncology, 14.2, 1959-1966 (2017)
    View All Related Papers

    Articles

    p53: DNA Damage Response and Cancer

    p53 regulates gene expression, cell cycle control and functions as a tumor suppressor. Inactivation of p53 is closely tied to cancer development.

    Cancer Stem Cells: Targets for Cancer Therapy

    Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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