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Merck
CN

P3556

Sigma-Aldrich

L-α-Phosphatidylcholine

egg yolk, Type XVI-E, ≥99% (TLC), lyophilized powder

Synonym(s):

1,2-Diacyl-sn-glycero-3-phosphocholine, 3-sn-Phosphatidylcholine, L-α-Lecithin, Azolectin, PC

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Select a Size

25 MG
CN¥958.88
100 MG
CN¥2,672.55
250 MG
CN¥4,356.08
1 G
CN¥13,780.54
5 X 1 G
CN¥52,741.19

CN¥958.88


Available to ship onApril 14, 2025Details


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25 MG
CN¥958.88
100 MG
CN¥2,672.55
250 MG
CN¥4,356.08
1 G
CN¥13,780.54
5 X 1 G
CN¥52,741.19

About This Item

CAS Number:
Beilstein:
5209585
EC Number:
UNSPSC Code:
51321705
NACRES:
NA.25

CN¥958.88


Available to ship onApril 14, 2025Details


Request a Bulk Order

biological source

egg yolk

Quality Level

type

Type XVI-E

Assay

≥99% (TLC)

form

lyophilized powder

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

ambient

storage temp.

−20°C

SMILES string

[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COC(=O)CCCCCCCCCCCCCCC)OCC[N+](C)(C)C

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This Item
D0260C9630A9376
Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

assay

≥96% (HPLC)

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥93%

color

off-white

color

white

color

-

color

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

Phosphatidylcholine belongs to the class of glycerophoshpolipids and contains choline as the head-group.[1] Choline is attached to the glycerol of fatty acids ester-bound to backbone.[1][2] It is the major phospholipid found in eukaryotic organism.[2]

Application

L-α-Phosphatidylcholine has been used:
  • to form a thin lipid film used in Kupffer cell depletion by liposome-encapsulated clodronate[3]
  • as a component of assay buffer used in γ-secretase in vitro assay[4]
  • in the preparation of substrate mix for its use in HPLC (high performance liquid chromatography) assay of 5-lipoxygenase enzyme activity[5]

Biochem/physiol Actions

A major structural phospholipid in brain, comprising approx. 15% of total lipid; primarily localized to gray matter.
It also acts as a source of lipid messengers/ bioactive lipids including: lysophosphatidylcholine, diacylglycerol, phosphatidic acid, lysophosphatidylcholine, arachidonic acid and platelet activating factor.[6] Phosphatidylcholine is produced in the liver by the CDP-choline (cytidine diphosphocholine) pathway.[7]

Packaging

Packaged under Argon

Preparation Note

Prepared by a modification of the procedure of Singleton, W.S., et al., J. Am. Oil Chem. Soc., 42, 53 (1965).

also commonly purchased with this product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

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Lea M Hürlimann et al.
Antimicrobial agents and chemotherapy, 60(9), 5400-5411 (2016-07-07)
Nosocomial infections with Enterococcus faecalis are an emerging health problem. However, drug efflux pumps contributing to intrinsic drug resistance are poorly studied in this Gram-positive pathogen. In this study, we functionally investigated seven heterodimeric ABC transporters of E. faecalis that
FTIR-spectroscopic characterization of phosphocholine-headgroup model compounds
Pohle W, et al.
Journal of Molecular Structure, 563, 463-467 (2001)
Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production
Rakonjac M, et al.
Proceedings of the National Academy of Sciences of the USA, 103(35), 13150-13155 (2006)
Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway
DeLong CJ, et al.
The Journal of Biological Chemistry, 274(42), 29683-29688 (1999)
Ireos Filipuzzi et al.
PLoS genetics, 12(11), e1006374-e1006374 (2016-11-18)
Invasive infections by fungal pathogens cause more deaths than malaria worldwide. We found the ergoline compound NGx04 in an antifungal screen, with selectivity over mammalian cells. High-resolution chemogenomics identified the lipid transfer protein Sec14p as the target of NGx04 and

Protocols

(soybean), ≥97%; L-α-Phosphatidylethanolamine from egg yolk, Type III, ≥97% (TLC), lyophilized powder; L-α-Phosphatidylcholine, from egg yolk, Type XVI-E, ≥99% (TLC), lyophilized powder; Sphingomyelin, from chicken egg yolk, ≥95%

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