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P3076

Sigma-Aldrich

Platelet-Derived Growth Factor-AA human

PDGF-AA, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

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Synonym(s):
PDGF−AA
MDL number:
MFCD00081862
UNSPSC Code:
12352202
NACRES:
NA.77

biological source

human

Quality Level

100

recombinant

expressed in E. coli

Assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

potency

1.0-3.0 ng/mL ED50

quality

endotoxin tested

mol wt

28.5 kDa (containing 250 amino acid residues)

packaging

pkg of 10 μg
pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

<1 EU/μg

UniProt accession no.

P04085

storage temp.

−20°C

Gene Information

human ... PDGFRA(5154)

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General description

Platelet-derived growth factor (PDGF) is composed two polypeptide subunits of A and B chain. PDGF is produced by a number of cells including smooth muscle cells, endothelial cells and macrophages. The PDGF gene is highly conserved and is mapped to human chromosome 7p22.3. PDGF is structurally and functionally related to vascular endothelial growth factors.

Biochem/physiol Actions

Cell division and relocalization of pulmonary artery smooth muscle cells and fibroblasts is known to be triggered by platelet-derived growth factor (PDGF). Due to its proliferatory function, it is associated with fibroproliferative disorders such as atherosclerosis, pulmonary arterial hypertension and lung fibrosis. PDGF exists both in homo and heterodimeric forms and stimulates α and β-cell surface receptors. Vascular endothelial growth factor expression is regulated by PDGF-AA autocrine signalling and is known to promote tumor angiogenesis in vivo.

Other Notes

Homodimer of the A chain of human PDGF.

Physical form

Sterile-filtered through a 0.2 μm filter. Lyophilized with 10 mM acetic acid.

Analysis Note

The biological activity is measured by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells.

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Role of platelet-derived growth factors in physiology and medicine.
Andrae J, et al.
Genes & Development, 22.10, 1276-1312 (2008)
Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non?small cell lung carcinomas.
Shikada Y, et al.
Cancer Research, 65.16, 7241-7248 (2005)
Clinical Findings Associated with a De Novo Partial Trisomy 10p11. 22p15. 3 and Monosomy 7p22. 3 Detected by Chromosomal Microarray Analysis.
Kohannim O, et al.
Case Reports in Genetics, 2011 (2011)
Luana Abballe et al.
Frontiers in pediatrics, 6, 315-315 (2018-11-18)
Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development. Additionally, Numb functions as cell fate determinant of stem cells and cancer stem cells
Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension.
Perros F, et al.
American Journal of Respiratory and Critical Care Medicine, 178.1, 81-88 (2008)
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Articles

Platelet Derived Growth Factors (PDGF)

Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.

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