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P215

Sigma-Aldrich

PD 98,059

solid

Synonym(s):

2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059

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About This Item

Empirical Formula (Hill Notation):
C16H13NO3
CAS Number:
167869-21-8
Molecular Weight:
267.28
MDL number:
MFCD00671789
UNSPSC Code:
12352200
PubChem Substance ID:
24278666
NACRES:
NA.77

form

solid

Quality Level

100

color

yellow

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

COc1cccc(c1N)C2=CC(=O)c3ccccc3O2

InChI

1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3

InChI key

QFWCYNPOPKQOKV-UHFFFAOYSA-N

Gene Information

human ... MAP2K1(5604) , MAP2K2(5605) , MAP2K3(5606) , MAP2K4(6416) , MAP2K5(5607) , MAP2K6(5608) , MAP2K7(5609) , MAP3K1(4214) , RAF1(5894)

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Application

PD 98,059 has been used:
  • in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors
  • in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown
  • in culture medium for cell migration assay

Biochem/physiol Actions

PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold with permission of Warner Lambert Company.

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sepsis: Advances in Research and Treatment: 2011 Edition, 38-38 (2012)
D T Dudley et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(17), 7686-7689 (1995-08-15)
Treatment of cells with a variety of growth factors triggers a phosphorylation cascade that leads to activation of mitogen-activated protein kinases (MAPKs, also called extracellular signal-regulated kinases, or ERKs). We have identified a synthetic inhibitor of the MAPK pathway. PD
PACAP and VIP inhibit the invasiveness of glioblastoma cells exposed to hypoxia through the regulation of HIFs and EGFR expression
Maugeri G, et al.
Frontiers in Pharmacology, 7, 139-139 (2016)
PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase
Reiners JJ, et al.
Molecular Pharmacology, 53(3), 438-445 (1998)
Ki-Sun Park et al.
Nucleic acids research, 45(22), 12766-12779 (2017-12-16)
Imprinted genes occur in discrete clusters that are coordinately regulated by shared DNA elements called Imprinting Control Regions. H19 and Igf2 are linked imprinted genes that play critical roles in development. Loss of imprinting (LOI) at the IGF2/H19 locus on
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