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General description
Pepsinogen II is an aspartic protease produced majorly in the gastric chief cells. It is broadly dispersed in the gastrointestinal tract of various species. Pepsinogen II is a seminal plasma protein, which also exists as a zymogen in gastric mucosa. It comprises chiefly of β-sheets with a substrate-binding cleft. The cleft is situated between the two lobes consisting of two catalytic-site aspartates (Asp32 and Asp215). Pepsinogen II gene is mapped to the human chromosome 6p21.1.
Biochem/physiol Actions
Pepsinogen II functions as a proteolytic enzyme of gastric secretion. It also exhibits aspartyl proteinase-like features. Pepsinogen II degrades dietary proteins in the stomach, whereas it stimulates defensins for local antimicrobial defense in seminal fluids. Pepsinogen II is critical in processing the secretory pathway of alveolar type-2 cells. It is also used as a marker in several neoplasms and cancers.
The ratio between serum levels of pepsinogens I and II can be determined to identify patients with high risk of gastric cancer.
Used as a marker of gastric mucosa status.
Physical form
Liquid, 20 mM Tris-HCl, pH 8.0
Storage Class Code
10 - Combustible liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Kimihiko Yanaoka et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17(4), 838-845 (2008-04-10)
Gastric cancer screening using the pepsinogen filter test is receiving wide recognition in Japan owing to convenience, freedom from discomfort or risk, efficiency, and economy. Because the long-term outcomes of cancer development in extensive atrophic gastritis detected by pepsinogen test
Cherie Foster et al.
American journal of physiology. Lung cellular and molecular physiology, 286(2), L382-L387 (2003-10-28)
Pepsinogen C, also known as progastricsin or pepsinogen II, is an aspartic protease expressed primarily in gastric chief cells. Prior microarray studies of an in vitro model of type 2 cell differentiation indicated that pepsinogen C RNA was highly induced
Md Imtaiyaz Hassan et al.
Journal of molecular cell biology, 2(3), 118-127 (2010-03-17)
Progastricsin (PGC) is a major seminal plasma protein having aspartyl proteinases-like activity and showing close sequence similarity to pepsins. PGC is also present as zymogen in gastric mucosa. In this article, we have reviewed all important features of PGC. Furthermore
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