N1408
NGF-β human
from human, recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
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Synonym(s):
HSAN5, NGFB, hNGFβ
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biological source
human
Quality Level
recombinant
expressed in NSO cells
Assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
0.15-3.0 ng/mL ED50/EC50
quality
endotoxin tested
packaging
pkg of 5X0.1 mg
pkg of 0.1 mg
technique(s)
cell culture | mammalian: suitable
impurities
<1 EU/μg
solubility
water: soluble 0.1 g/L at 20 °C
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... NGF(4803)
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General description
The nerve growth factor β (NGFB) gene is mapped to human chromosome 1p13.2.
Application
NGF-β human has been used:
- in protein pin arrays
- to induce U87-MG (glioblastoma cell line) cell proliferation
- in drug release kinetics
Biochem/physiol Actions
Nerve growth factor β (NGFB) acts as a key mediator in neuronal and non-neuronal development, differentiation, and survival. Polymorphism of NGFB gene leads to hereditary sensory and autonomic neuropathies. Charcot arthropathy and thermal insensitivity are few of the related symptoms. NGFβ is known to promote cancer cell proliferation and metastasis, also mediates angiogenesis. It facilitates the development of various cancer including, oral, breast, lungs, pancreatic and prostate cancers. Elevated expression of NGFβ contributes to progression of human cholangiocarcinoma. In animal models, NGFβ is observed to prevent cholinergic neuron loss and enhances memory. NGF-β promotes the survival and cholinergic phenotype of basal forebrain cholinergic neurons and stimulates neurite outgrowth of embryonic trigeminal motor neurons in vitro.
Physical form
Lyophilized from 0.2% acetic acid containing 5 mg bovine serum albumin.
Analysis Note
The biological activity is measured in a cell proliferation assay using a factor-dependent human erythroleukemic cell line, TF-1.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Certificates of Analysis (COA)
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Mahmoud Aarabi et al.
Fertility and sterility, 102(2), 440-447 (2014-06-09)
To determine the levels of postacrosomal WW binding protein (PAWP) in the spermatozoa of men that were used clinically for intracytoplasmic sperm injection (ICSI) and to correlate them with infertility treatment outcomes. Prospective clinical and laboratory study. University-based laboratory and
S Korsching
The Journal of neuroscience : the official journal of the Society for Neuroscience, 13(7), 2739-2748 (1993-07-01)
The neurotrophic factor concept in its basic form envisages that innervated tissues produce a signal for the innervating neurons for the selective limitation of neuronal death occurring during development (Purves, 1986; Oppenheim, 1991). This concept arose several decades ago on
Nerve Growth Factor Stimulates Glioblastoma Proliferation through Notch1 Receptor Signaling
Park JC, et al.
Journal of Korean Neurosurgical Society, 61(4), 441-441 (2018)
K A Crutcher et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 13(6), 2540-2550 (1993-06-01)
A two-site ELISA and a bioassay were used to detect NGF-like activity in human brain tissue. Both assays detected mouse NGF and recombinant human NGF with approximately equal sensitivity, whereas the antibodies showed little cross-reactivity with the recombinant human proteins
Expression of NGF, GDNF and MMP-9 in prostate carcinoma
Baspinar S, et al.
Pathology, research and practice, 213(5), 483-489 (2017)
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