MAK200
Cathepsin B Inhibitor Screening Kit
Sufficient for 100 Fluorometric tests
Synonym(s):
CTSB Inhibitor Screening Kit
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.25
Recommended Products
detection method
fluorometric
storage temp.
−20°C
Gene Information
human ... CTSB(1508)
mouse ... CTSB(13030)
rat ... CTSB(64529)
General description
Cathepsin B (CTSB; EC 3.4.22.1) is a lysosomal cysteine proteinase involved in intracellular degradation and turnover of proteins. It is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP is a causative factor in Alzheimer′s disease. CTSB has also been implicated in the invasion and metastasis of certain cancers.
The Cathepsin B Inhibitor Screening Kit is a simple assay for screening potential inhibitors of CTSB. CTSB activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λex = 400/λem = 505 nm), proportional to the enzymatic activity present.
The Cathepsin B Inhibitor Screening Kit is a simple assay for screening potential inhibitors of CTSB. CTSB activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λex = 400/λem = 505 nm), proportional to the enzymatic activity present.
Suitability
Suitable for the screening of inhibitors of Cathepsin B.
Principle
The Cathepsin B Inhibitor Screening Kit is a simple assay for screening potential inhibitors of CTSB. CTSB activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λex = 400/λem = 505 nm), proportional to the enzymatic activity present.
Kit Components Only
Product No.
Description
- CTSB Reaction Buffer
- CTSB Reagent
- Cathepsin B, human
- CTSB Substrate, Ac-RR-AFC, 10 mM
- CTSB Inhibitor, F-F-FMK, 1 mM
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2
Storage Class Code
10 - Combustible liquids
Regulatory Information
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Lucas Paoli et al.
Nature, 607(7917), 111-118 (2022-06-23)
Natural microbial communities are phylogenetically and metabolically diverse. In addition to underexplored organismal groups1, this diversity encompasses a rich discovery potential for ecologically and biotechnologically relevant enzymes and biochemical compounds2,3. However, studying this diversity to identify genomic pathways for the
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