M8046
Mifepristone
≥98%
Synonym(s):
11β-(4-Dimethylamino)phenyl-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one, RU-38486, RU-486
About This Item
Recommended Products
biological source
synthetic (organic)
sterility
non-sterile
Assay
≥98%
form
powder
technique(s)
inhibition assay: suitable
solubility
ethanol: 50 mg/mL, clear, greenish-yellow
originator
Danco Laboratories
shipped in
ambient
storage temp.
2-8°C
SMILES string
[H][C@@]12CCC3=CC(=O)CCC3=C1[C@H](C[C@@]4(C)[C@@]2([H])CC[C@@]4(O)C#CC)c5ccc(cc5)N(C)C
InChI
1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
InChI key
VKHAHZOOUSRJNA-GCNJZUOMSA-N
Gene Information
human ... AR(367) , ESR1(2099) , ESR2(2100) , HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , NR3C1(2908) , NR3C2(4306) , PGR(5241)
mouse ... Nr3c1(14815)
rat ... Nr3c1(24413) , Tat(24813)
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General description
Application
- to induce damage against the proliferative and secretory phase of endometrial stromal cells
- to establish a preterm birth (PTB) mice model in order to study the difference in cervical ripening mechanism between term and PTBs
- to activate geneswitch gal4 in flies
- to study the effects of sex steroids on prostaglandin secretion
Biochem/physiol Actions
Features and Benefits
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 1B
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
Regulatory Information
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Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
What is Mifepristone, Product M8046, soluble in?
Mifepristone is soluble in ethanol at 50 mg/mL; heat may be required to dissolve the compound at this concentration. It is also soluble in DMSO at 20 mg/mL.
Can solutions of Mifepristone, Product M8046, be stored?
Stock solutions of 1 mM mifepristone in ethanol can be stored at -20 °C. The top of the container should be sealed with Parafilm to prevent solvent evaporation. Solutions in ethanol, properly stored and handled, are probably good for several months (based on the structure of the compound), but we have no specific information on this.
Where can I find information on usage of Mifepristone, Product M8046?
The Sigma-Aldrich website listing has several cited articles with hyperlinks to the abstracts. These references can be found under the reference tab on the M8046 product webpage.
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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