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M6518

Macrophage Colony-Stimulating Factor human

≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

MCSF

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00166591

Key Documents

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Product Name

Macrophage Colony-Stimulating Factor human, M-CSF, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

human

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

potency

0.500-5.000 ng/mL ED50

quality

endotoxin tested

mol wt

dimer 37 kDa

packaging

pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

impurities

≤1.000 EU/μg

color

white

UniProt accession no.

P09603

storage temp.

−20°C

Quality Level

200

Gene Information

human ... CSF1(1435)

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Analysis Note

The proliferative activity is tested in culture using the cytokine-dependent murine monocytic cell line M-NFS-60 cells.

Application

Macrophage Colony-Stimulating Factor human has been used for the differentiation of bone marrow-derived macrophages (BMDMs) and human monocyte-derived macrophages (MDMs). It has also been used for cell culture.

Biochem/physiol Actions

Macrophage colony-stimulating factor (M-CSF) augments many of the physiological functions of macrophages, and support osteoclast differentiation.

General description

Macrophage Colony-Stimulating Factor (M-CSF) is a hematopoietic growth factor, which modulates the proliferation, differentiation and functional activation of monocytes. It is produced by fibroblasts, endothelial cells and bone marrow stromal cells. MCSF stimulates the functions of mature monocytes and macrophages.

Other Notes

159 amino acids including N-terminal methionine (each monomer).

Physical form

Lyophilized from a sterile filtered buffered solution.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000359450
0000359450
0000240228
0000240228
0000162874

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Theranostics, 9(16), 4648-4662 (2019-08-02)
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Kim JK, et al.
Autophagy, 13(2), 423-441 (2017)
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