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Merck
CN

M1555

MAHMA NONOate

Synonym(s):

6-(2-Hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-hexanamine, NOC-9

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About This Item

Empirical Formula (Hill Notation):
C8H20N4O2
CAS Number:
Molecular Weight:
204.27
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
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Quality Level

shipped in

dry ice

storage temp.

−70°C

SMILES string

[H][N+]([H])(C)CCCCCCN(C)N([O-])N=O

InChI

1S/C8H19N4O2/c1-9-7-5-3-4-6-8-11(2)12(14)10-13/h9H,3-8H2,1-2H3/q-1/p+1

InChI key

WASRCWNCCFPNEJ-UHFFFAOYSA-O

Application

NO donor

Biochem/physiol Actions

NO release: t1/2 = 3 min (phosphate buffer at 22° C)


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Articles

Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.

一氧化氮 (NO) 是神经元、内皮细胞和免疫系统中的信号转运分子。


A M Vincent et al.
Journal of neurobiology, 40(2), 171-184 (1999-07-21)
Neuronal injury is intricately linked to the activation of three distinct neuronal endonucleases. Since these endonucleases are exquisitely pH dependent, we investigated in primary rat hippocampal neurons the role of intracellular pH (pH(i)) regulation during nitric oxide (NO)-induced toxicity. Neuronal
Zhao Zhong Chong et al.
Current neurovascular research, 2(3), 197-211 (2005-09-27)
Metabotropic glutamate receptors (mGluRs) are expressed throughout the mammalian central nervous system and integrate a host of signal transduction pathways that determine cellular function, plasticity and injury. Yet, one of the more unique regulatory functions of this family of GTP-binding
Mauricio Di Fulvio et al.
American journal of physiology. Heart and circulatory physiology, 284(5), H1686-H1692 (2003-01-11)
Nitric oxide (NO) donors regulate KCl cotransport (KCC) activity and cotransporter-1 and -3 (KCC1 and KCC3) mRNA expression in sheep erythrocytes and in primary cultures of rat vascular smooth muscle cells (VSMCs), respectively. In this study, we used NONOates as



Global Trade Item Number

SKUGTIN
M1555-50MG04061834040903