Skip to Content

Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

Merck
CN
All Photos(1)

Key Documents

View All Documentation

L4395

Sigma-Aldrich

Liposome Kit: Lipid mixtures for the preparation of liposomes

lyophilized powder

Synonym(s):

cholesterol, L-α-phosphatidylcholine and stearylamine kit

Sign Into View Organizational & Contract Pricing

Select a Size

1 VIAL
CN¥1,963.09
5 VIALS
CN¥4,950.78

CN¥1,963.09

Please contact Customer Service for Availability
Request a Bulk Order
All Photos(1)

Select a Size

Change View
1 VIAL
CN¥1,963.09
5 VIALS
CN¥4,950.78

About This Item

EC Number:
204-695-3
UNSPSC Code:
12352211
NACRES:
NA.25

CN¥1,963.09

Please contact Customer Service for Availability
Request a Bulk Order

biological source

egg yolk

Quality Level

200

form

lyophilized powder

composition

Cholesterol, 9 μmol/package
L-α-Phosphatidylcholine (egg yolk), 63 μmol/package
Stearylamine, 18 μmol/package

functional group

carboxylic acid

shipped in

ambient

storage temp.

−20°C

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
L4754P539461755
Liposome Kit: Lipid mixtures for the preparation of liposomes lyophilized powder

L4395

Liposome Kit: Lipid mixtures for the preparation of liposomes

3-sn-Lysophosphatidylethanolamine from egg yolk Type I, ≥99%

L4754

3-sn-Lysophosphatidylethanolamine from egg yolk

L-α-Phosphatidylcholine from dried egg yolk, Type X-E, ≥40% (enzymatic)

P5394

L-α-Phosphatidylcholine

L-α-Phosphatidylcholine egg yolk, ~60% (TLC)

61755

L-α-Phosphatidylcholine

functional group

carboxylic acid

functional group

-

functional group

phospholipid

functional group

phospholipid

biological source

egg yolk

biological source

egg yolk

biological source

egg yolk (dried)

biological source

egg yolk

form

lyophilized powder

form

powder

form

solid

form

solid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

Application

Liposome Kit has been used for the preparation of liposomes.[1][2][3]

Biochem/physiol Actions

Liposome Kit: Lipid mixtures for the preparation of liposomes contains cholesterol; L-α-phosphatidylcholine and stearylamine. Liposome kit may be used to prepare cationic (positively charge) liposomes for incorporation of materials into cells.
Liposomes can be used for different applications such as drug delivery, diagnostics, membrane models, adjuvants for vaccination and others. This lipid mixture can be used to encapsulate a broad spectrum of hydrophilic and amphipathic molecules of low, medium, and high molecular weight (including peptides, proteins, and oligo- and polynucleotides).

related product

Product No.
Description
Pricing

Pictograms

CorrosionEnvironment
GHS05,GHS09

Signal Word

Danger

Hazard Statements

H318,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

  • Specification Sheet

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    0000418690
    0000404712
    0000404712
    0000418690
    0000408426

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Search for a COA

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    1. Which document(s) contains shelf-life or expiration date information for a given product?

      If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

    2. How do I get lot-specific information or a Certificate of Analysis?

      The lot specific COA document can be found by entering the lot number above under the "Documents" section.

    3. I have purchased Product L4395, Liposome Kit.  Is there a difference between positive and negative liposomes?

      The choice is dependent upon what is being encapsulated and how it is being used.  A good reference discussing this question is Ogiso, T., et al., Effect of positively and negatively charged liposomes on skin permeation of drugs. J. Drug Target, 9(1), 49-59 (2001).

    4. How is Product L4395, Liposome Kit, used?

      The Liposomes of a large multilamellar structure type are the most widely used. They can be prepared using Sigma liposome mixtures by concentrating an organic solvent solution of lipids to a thin film on the walls of a container such as by rotary evaporation or by drying in glass with a stream of nitrogen gas. Then, under appropriate conditions, an aqueous solution is added to the thin film and with agitation multilamellar vesicles should form spontaneously with little effort. Large or small unilamellar structured liposomes can also be prepared by varying procedure or conditions. Please see the product insert for Product No. L4031 (the link below) for a step by step protocol that will work for this product also.

    5. How do I prepare the Product L4395, Liposome Kit liposomes?

      Refer to the product information sheet (under Documents, above) for L4031 for preparation information.

    6. I'm thinking of purchasing Product L4395, Liposome Kit.  Why would one use positive vs. negative liposomes?

      Analogous to poly-L-lysine, one may need positively charged agents to deliver drugs to cells, hence positive liposomes.

    7. How do I find price and availability?

      There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

    8. What is the Department of Transportation shipping information for this product?

      Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

    9. My question is not addressed here, how can I contact Technical Service for assistance?

      Ask a Scientist here.

    Rui Xu et al.
    Analytical chemistry, 88(21), 10390-10394 (2016-11-02)
    Chemical analysis of small extracellular vesicles (sEVs) circulating in body fluids holds potentials in noninvasive diagnosis of diseases and evaluation of therapeutic treatments. However, quantification of sEVs remains a challenge due to lacking of cost-effective analytical protocols. Herein we report
    Quantification of small extracellular vesicles by size exclusion chromatography with fluorescence detection
    Xu R, et al.
    Analytical Chemistry, 88(21), 10390-10394 (2016)
    Sub-Micrometric Liposomes as Drug Delivery Systems in the Treatment and Periodontitis
    Di Turi G, et al.
    International Journal of Immunopathology and Pharmacology, 25(3), 657-670 (2012)
    Giulietta Pinato et al.
    Journal of biomedical optics, 16(9), 095001-095001 (2011-09-29)
    Spatially confined and precise time delivery of neuroactive molecules is an important issue in neurophysiology. In this work we developed a technique for delivering chemical stimuli to cultured neurons consisting in encapsulating the molecules of interest in liposomes. These vectors
    G T Köse et al.
    Drug delivery, 5(4), 257-264 (1998-01-01)
    Multilamellar vesicles (MLV) containing phosphatidyl choline (PC), cholesterol (CHOL), and stearylamine (SA) in the molar ratio of 7:2:0.2 were prepared by the thin film hydration method. Low-molecular-weight heparin (LMWH, MW: 3000) was conjugated with the MLV using carbodiimide (EDC). Infrared
    View All Related Papers

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service