L4395
Liposome Kit: Lipid mixtures for the preparation of liposomes
lyophilized powder
Synonym(s):
cholesterol, L-α-phosphatidylcholine and stearylamine kit
About This Item
Recommended Products
biological source
egg yolk
Quality Level
form
lyophilized powder
composition
Cholesterol, 9 μmol/package
L-α-Phosphatidylcholine (egg yolk), 63 μmol/package
Stearylamine, 18 μmol/package
functional group
carboxylic acid
shipped in
ambient
storage temp.
−20°C
Related Categories
Application
Biochem/physiol Actions
related product
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Certificates of Analysis (COA)
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Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
I have purchased Product L4395, Liposome Kit. Is there a difference between positive and negative liposomes?
The choice is dependent upon what is being encapsulated and how it is being used. A good reference discussing this question is Ogiso, T., et al., Effect of positively and negatively charged liposomes on skin permeation of drugs. J. Drug Target, 9(1), 49-59 (2001).
How is Product L4395, Liposome Kit, used?
The Liposomes of a large multilamellar structure type are the most widely used. They can be prepared using Sigma liposome mixtures by concentrating an organic solvent solution of lipids to a thin film on the walls of a container such as by rotary evaporation or by drying in glass with a stream of nitrogen gas. Then, under appropriate conditions, an aqueous solution is added to the thin film and with agitation multilamellar vesicles should form spontaneously with little effort. Large or small unilamellar structured liposomes can also be prepared by varying procedure or conditions. Please see the product insert for Product No. L4031 (the link below) for a step by step protocol that will work for this product also.
How do I prepare the Product L4395, Liposome Kit liposomes?
Refer to the product information sheet (under Documents, above) for L4031 for preparation information.
I'm thinking of purchasing Product L4395, Liposome Kit. Why would one use positive vs. negative liposomes?
Analogous to poly-L-lysine, one may need positively charged agents to deliver drugs to cells, hence positive liposomes.
How do I find price and availability?
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What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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