300205S
Avanti
Pegylated Remote Loadable Liposome (5 mL)
Avanti Polar Lipids
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Synonym(s):
Pegylated Remote Loadable Liposome
UNSPSC Code:
12352211
NACRES:
NA.25
Recommended Products
form
aqueous solution
packaging
pkg of 1 × 5 mL
manufacturer/tradename
Avanti Polar Lipids
shipped in
dry ice
storage temp.
−20°C
General description
Liposomes are artificial phospholipid vesicles, used to encapsulate and stabilize the drugs and improve their pharmacological properties. PEGylated liposomes are the liposomes modified on the surface with polyethylene glycol (PEG). This PEGylation prevents adsorption of plasma proteins to the liposome surface. This blocks the recognition and uptake of liposomes by the reticoloendothelial system (RES), thereby extending the circulation time of liposomes. PEGylated liposomes (PEGlip) aids in improving the pharmacodynamic properties of therapeutic proteins. PEGlip improves passive targeting ability on tumoral tissues by a process called enhanced permeation retention effect. It enhances the therapeutic effect of the drug and reduces the toxicity of encapsulated drug. The characteristics of PEGlip depends on the PEG linked to the surface, graft density and the distance between graft sites. PEGlyation with greater PEG chains improves the blood residence time.
Packaging
10 mL Clear Glass Vial with Stopper and Crimp Cap (300205S-1EA)
WGK
WGK 2
Certificates of Analysis (COA)
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PEGylation of proteins and liposomes: a powerful and flexible strategy to improve the drug delivery
Milla P, et al.
Current Drug Metabolism, 13(1), 105-119 (2012)
The use of PEGylated liposomes in the development of drug delivery applications for the treatment of hemophilia
Yatuv R, et al.
International journal of nanomedicine, 5, 581-581 (2010)
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