K4643
PKCθ, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
MGC126514, MGC141919, PRKCQ, PRKCT, nPKC-theta
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
recombinant
expressed in baculovirus infected Sf9 cells
Quality Level
product line
PRECISIO® Kinase
Assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
673-911 nmol/min·mg
mol wt
~110 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PRKCQ(5588)
General description
PKCθ (protein kinase C θ) is a serine/threonine kinase, belonging to protein kinase C family.
Biochem/physiol Actions
PKCθ (protein kinase C θ) is required for T cell activation and proliferation. In presence of TCR (T cell receptor) stimulation, it is responsible for activation of NF-AT (nuclear factor of activated T-cells), NF-κB (nuclear factor κ B) and AP1 (adaptor-related protein complex 1). It might be a target for the treatment of type 2 diabetes. PKCθ is needed for fat-mediated insulin resistance in skeletal muscle.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
新产品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Santhakumar Manicassamy et al.
Journal of immunology (Baltimore, Md. : 1950), 178(1), 312-319 (2006-12-22)
A functional immune system not only requires rapid expansion of antigenic specific T cells, but also requires efficient deletion of clonally expanded T cells to avoid accumulation of T cells. Fas/Fas ligand (FasL)-mediated apoptosis plays a critical role in the
J Rennecke et al.
European journal of biochemistry, 242(2), 428-432 (1996-12-01)
13 murine tissues and 12 cell lines were tested for the expression of the novel protein kinase C (PKC) isoenzyme mu. Using two different PKC mu antibodies (sc-639 and P26720), PKC mu was detected in all tissues and cells and
Jason K Kim et al.
The Journal of clinical investigation, 114(6), 823-827 (2004-09-17)
Insulin resistance plays a primary role in the development of type 2 diabetes and may be related to alterations in fat metabolism. Recent studies have suggested that local accumulation of fat metabolites inside skeletal muscle may activate a serine kinase
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service