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Safety Information

J2753

Sigma-Aldrich

JWH-133

solid

Synonym(s):

3-(1,1-Dimethylbutyl)-1-deoxy-Δ8-THC, 3-(1,1-Dimethylbutyl)-1-deoxy-Δ8-tetrahydrocannabinol

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About This Item

Empirical Formula (Hill Notation):
C22H32O
CAS Number:
259869-55-1
Molecular Weight:
312.49
MDL number:
MFCD06795847
UNSPSC Code:
12352200
PubChem Substance ID:
24896193

form

solid

drug control

USDEA Schedule I; Home Office Schedule 1; regulated under CDSA - not available from Sigma-Aldrich Canada

color

white

solubility

DMSO: <0.16 mg/mL
H2O: <0.28 mg/mL
ethanol: 11 mg/mL

storage temp.

−20°C

SMILES string

CCCC(C)(C)c1ccc2[C@@H]3CC(C)=CC[C@H]3C(C)(C)Oc2c1

Gene Information

human ... CNR2(1269)
mouse ... Cnr1(12801) , Cnr2(12802)

Biochem/physiol Actions

Selective CB2 cannabinoid receptor agonist.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
070K4701

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Jörg Reifart et al.
Transplantation, 99(1), 41-47 (2014-11-02)
CD4+ T cells play a critical role during hepatic ischemia-reperfusion (I/R) injury although the mechanisms of their migration in the postischemic liver remain unclear. We answered the questions of whether hepatic stellate cells (HSCs) interact with CD4+ T cells during
Tianshui Yu et al.
Histology and histopathology, 30(6), 737-749 (2015-01-16)
The aim of the current study was to investigate the effects of cannabinoid receptor type 2 (CB2R) on the repair process of injured skeletal muscle, which could potentially lay solid foundations as a novel target for curing muscular fibrosis in
Weisi Fu et al.
Neuroscience letters, 595, 1-6 (2015-04-08)
Clinical trials investigating the analgesic efficacy of cannabinoids in multiple sclerosis have yielded mixed results, possibly due to psychotropic side effects mediated by cannabinoid CB1 receptors. We hypothesized that, a CB2-specific agonist (JWH-133) would decrease hyperalgesia in an experimental autoimmune
J W Huffman et al.
Bioorganic & medicinal chemistry, 7(12), 2905-2914 (2000-02-05)
The synthesis and pharmacology of 15 1-deoxy-delta8-THC analogues, several of which have high affinity for the CB2 receptor, are described. The deoxy cannabinoids include 1-deoxy-11-hydroxy-delta8-THC (5), 1-deoxy-delta8-THC (6), 1-deoxy-3-butyl-delta8-THC (7), 1-deoxy-3-hexyl-delta8-THC (8) and a series of 3-(1',1'-dimethylalkyl)-1-deoxy-delta8-THC analogues (2, n
Francisco J Carrillo-Salinas et al.
PloS one, 9(4), e94733-e94733 (2014-04-15)
Phytocannabinoids that do not produce psychotropic effects are considered of special interest as novel therapeutic agents in CNS diseases. A cannabigerol quinone, the compound VCE-003, has been shown to alleviate symptoms in a viral model of multiple sclerosis (MS). Hence
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