I2778
Interleukin-1α human
IL-1α, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
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Synonym(s):
IL-1α, hIL-1α., Interleukin-1α human, Lymphocyte activating factor
Recommended Products
biological source
human
Quality Level
recombinant
expressed in E. coli
Assay
≥98% (SDS-PAGE and HPLC)
form
lyophilized powder
quality
endotoxin tested
mol wt
~17 kDa
packaging
pkg of 2 and 10 μg
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IL1A(3552)
Related Categories
General description
Interleukin-1α (IL-1α) is a cytokine that belongs to the interleukin-1 (IL-1) family. It is located intracellularly in hematopoietic and non-hematopoietic cells. IL-1α gene is located on the human chromosome at 2q14.1.
Application
Interleukin-1α (IL-1α) has been used:
- to study its effects on human colorectal adenocarcinoma cells
- to stimulate primary human fetal retinal pigment epithelium (hfRPE) cells
- to pre-stimulate human THP-1 monocytes
Biochem/physiol Actions
Interleukin-1α (IL-1α) plays a crucial role in inflammation during cell necrosis. It also regulates the recruitment of interleukin-1β (IL-1β), neutrophils, chemokines, and other cytokines at the site of injury. IL-1α exhibits a dual function of binding to its cell surface receptor as well as chromatin.
Physical form
Lyophilized from 0.2 μm filtered 10 mM sodium phosphate , pH 8.0, plus 50 mm NaCl and 50 μg bovine serum albumin (BSA) per μg cytokine.
Analysis Note
The proliferative activity of human IL-1α is tested in culture using the murine cell line D10S.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
常规特殊物品
含少量动物源组分生物产品
Certificates of Analysis (COA)
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Nelson C Di Paolo et al.
Nature immunology, 17(8), 906-913 (2016-07-21)
Inflammation occurs after disruption of tissue homeostasis by cell stress, injury or infection and ultimately involves the recruitment and retention of cells of hematopoietic origin, which arrive at the affected sites to resolve damage and initiate repair. Interleukin 1α (IL-1α)
Niklas Palmqvist et al.
Journal of inflammation (London, England), 13, 20-20 (2016-06-25)
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic eczematous lesions that are commonly treated with topical corticosteroids and calcineurin inhibitors. Side-effects and safety concerns associated with these agents restrict their use, and new, safe treatment
Romain Duroux et al.
International journal of cosmetic science, 44(6), 614-624 (2022-08-19)
A critical and often-overlooked factor that may give rise to dandruff and oily hair is the intrinsic quality of the scalp stratum corneum (SC), which is often unbalanced and susceptible to external aggressions. Addressing the inflammation element of unhealthy scalp
Ivo C J H Post et al.
Xenotransplantation, 20(1), 18-26 (2013-01-26)
Endothelial damage is a critical step in the development of (xeno) transplantation-related and cardiovascular pathology. In humans, the amount of circulating endothelial cells (CEC) correlates to disease intensity and functions as a valuable damage marker. While (xeno) transplantation and cardiovascular
Association of interleukin1 beta, interleukin1 receptor antagonist, interleukin 6 and angiotensin II receptor type I gene polymorphisms with end stage renal disease: A meta-analysis
Divya M, et al.
Gene Reports, 100856-100856 (2020)
Articles
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
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