Normal Human Characterized Plateable Hepatocytes Spheroid Qualified

Lot specific orders are not able to be placed through the web. Contact your local sales rep for more details. Primary Human Hepatocytes are cells directly harvested from whole human livers and are used by researchers in vitro to model the physiology and function of Hepatocytes. As one of the major cell types of the liver, Hepatocytes function in protein, carbohydrate, and lipid metabolism and help to maintain liver homeostasis. Our portfolio of plateable Hepatocytes includes spheroid-qualified Hepatocytes for 3D cell culture applications.

While plateable and suspension Hepatocytes are ideal for 2D cell culture applications, the spheroid-qualified plateable Hepatocytes can provide more relevant models for applications such as enzyme induction, toxicity, drug screening, transporter efflux activity, potential drug-drug interactions, and disease modeling.

Our collection of spheroid-qualified plateable Hepatocyte is isolated from whole human livers and consists of a homogenous population of cells, with each donor providing documented consent for research use of non-transplantable organs or tissues. Every lot is guaranteed to contain a minimum of 4 million viable cells per vial, maintaining a post-thaw viability of ≥70%. These Hepatocytes undergo extensive characterization, encompassing mRNA induction data and enzyme profiling data. Additionally, they are validated to form 3D spheroids when cultured for a minimum of 7 days. In addition, all cells have been tested for the absence of HIV, HBV, HCV, Syphillis and microbial contaminants (fungi, bacteria, and mycoplasma).

Each donor is tested and found non-reactive to viral DNA from HIV-1, HIV-2, HTLV I, HTLV II, hepatitis B and hepatitis C. However, no known test can offer complete assurance that the viruses that cause HIV-1, HIV-2, HTLV I, HTLV II, hepatitis B and hepatitis C are not present. Proper precautions and biological containment should be taken when handling cells of human origin, due to their potential biohazardous nature. All human based products should be handled at a BSL-2 (Biosafety Level 2) or higher.

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.