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HLP104

Normal Human Characterized Plateable Hepatocytes Spheroid Qualified

human liver

Synonym(s):

Homogenous population isolated from whole human livers

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About This Item

UNSPSC Code:
41106509
NACRES:
NA.81
Biological source:
human liver

Key Documents

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Product Name

Normal Human Characterized Plateable Hepatocytes Spheroid Qualified, Single-Donor Cryopreserved Primary Human Hepatocytes, suitable for 3D cell culture with Spheroid formation at >5 days, characterized for mRNA induction and metabolic assay profiling.

biological source

human liver

form

frozen liquid

packaging

pkg of 1 vial (contains ≥4 million cells)

technique(s)

cell culture | mammalian: suitable

color

cloudy

storage temp.

-140 to -196°C

General description

Lot specific orders are not able to be placed through the web. Contact your local sales rep for more details. Primary Human Hepatocytes are cells directly harvested from whole human livers and are used by researchers in vitro to model the physiology and function of Hepatocytes. As one of the major cell types of the liver, Hepatocytes function in protein, carbohydrate, and lipid metabolism and help to maintain liver homeostasis. Our portfolio of plateable Hepatocytes includes spheroid-qualified Hepatocytes for 3D cell culture applications.

Application

While plateable and suspension Hepatocytes are ideal for 2D cell culture applications, the spheroid-qualified plateable Hepatocytes can provide more relevant models for applications such as enzyme induction, toxicity, drug screening, transporter efflux activity, potential drug-drug interactions, and disease modeling.

Features and Benefits

Our collection of spheroid-qualified plateable Hepatocyte is isolated from whole human livers and consists of a homogenous population of cells, with each donor providing documented consent for research use of non-transplantable organs or tissues. Every lot is guaranteed to contain a minimum of 4 million viable cells per vial, maintaining a post-thaw viability of ≥70%. These Hepatocytes undergo extensive characterization, encompassing mRNA induction data and enzyme profiling data. Additionally, they are validated to form 3D spheroids when cultured for a minimum of 7 days. In addition, all cells have been tested for the absence of HIV, HBV, HCV, Syphillis and microbial contaminants (fungi, bacteria, and mycoplasma).

Disclaimer

Each donor is tested and found non-reactive to viral DNA from HIV-1, HIV-2, HTLV I, HTLV II, hepatitis B and hepatitis C. However, no known test can offer complete assurance that the viruses that cause HIV-1, HIV-2, HTLV I, HTLV II, hepatitis B and hepatitis C are not present. Proper precautions and biological containment should be taken when handling cells of human origin, due to their potential biohazardous nature. All human based products should be handled at a BSL-2 (Biosafety Level 2) or higher.
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Protocols

Primary Human Suspension Hepatocytes Culture Protocol

Explore our protocol for suspension primary hepatocyte cell culture. Discover our primary human hepatocytes and plating and maintenance media formulations.

Primary Human Hepatocytes Culture Protocol

Discover our primary human hepatocytes and plating and maintenance media formulations. Explore our protocol for plateable primary hepatocyte cell culture.

Primary Human Hepatic Stellate Cells Culture Protocol

Discover our collection of primary human hepatic stellate cells and protocol for thawing, plating, and growing stellate cells. Find our stellate culture maintenance media formulation.

Primary Human Intrahepatic Biliary Epithelial Cells (Cholangiocytes) Culture Protocol

Discover our primary human intrahepatic biliary epithelial cells, also known as cholangiocytes. Explore our plating and maintenance media formulations and protocol for culture.

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Related Content

User Guide-HLP104
Pre-tested, Cryopreserved, and Ready-to-Screen Human Primary Liver Cells

Explore our primary liver cells collection, including primary human Hepatocytes (PHH), spheroid-qualified Hepatocytes, Kupffer cells, Stellate cells, Cholangiocytes, and Sinusoidal Endothelial cells.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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