H8041
Interleukin-23 human
IL-23, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
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UNSPSC Code:
12352202
NACRES:
NA.77
Recommended Products
biological source
human
Quality Level
recombinant
expressed in HEK 293 cells
Assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
≤2 ng/mL EC50
quality
endotoxin tested
mol wt
dimer 55 kDa (glycosylated)
packaging
pkg of 5X10 μg
pkg of 10 μg
pkg of 5 μg
technique(s)
cell culture | mammalian: suitable
impurities
≤1EU/mg
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IL23A(51561)
Related Categories
General description
HumanKine interleukin-23 (IL-23) is expressed as a heterodimeric 55 kDa cytokine composed of two glycosylated and disulfide linked subunits (p40 cystine linked to p19). Production in human HEK 293 cells offers authentic glycosylation. Cytokines produced in Sf9 or Sf21 cells have post-translational modifications, which are not human-like.
Interleukin-23 (IL-23) is a pro-inflammatory cytokine. It is mostly synthesized by activated dendritic cells and macrophages. It is a 20.7kDa protein with 189 amino acids. IL-23 is mostly expressed on activated/memory T cells and natural killer (NK) cells. This gene is located on human chromosome 12q13.3.
Interleukin-23 (IL-23) is a pro-inflammatory cytokine. It is mostly synthesized by activated dendritic cells and macrophages. It is a 20.7kDa protein with 189 amino acids. IL-23 is mostly expressed on activated/memory T cells and natural killer (NK) cells. This gene is located on human chromosome 12q13.3.
Biochem/physiol Actions
Interleukin-23 (IL-23) plays a major role in cutaneous immune-mediated inflammatory diseases like psoriasis, allergic contact dermatitis and atopic dermatitis. It is involved in cellular immunity, driving the expansion, stabilization and survival of Th17 cells.
Analysis Note
The specific activity was determined by the dose-dependent secretion of h-IFN-γ or IL-8 from human PBMC.
Legal Information
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
WGK
WGK 1
Regulatory Information
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Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
IL23A (interleukin 23, alpha subunit p19)
Norimitsu I.
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 15(2) (2011)
Expression of IL-23/Th17-related cytokines in basal cell carcinoma and in the response to medical treatments
Cristina P, et al.
PLoS ONE, 12(8), e0183415-e0183415 (2017)
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