H7791
IL-17A human
HumanKine®, recombinant, Xeno-free, >95% (SDS-PAGE), suitable for cell culture
Synonym(s):
CTLA-8, Interleukin-17A human, IL-17
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About This Item
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
dimer 30-35 kDa (glycosylated)
Impurities:
≤1 EU/μg
Product Name
Interleukin-17A human, IL-17A, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
biological source
human
recombinant
expressed in HEK 293 cells
assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
≤2 ng/mL EC50
quality
endotoxin tested
mol wt
dimer 30-35 kDa (glycosylated)
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
impurities
≤1 EU/μg
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... IL17A(3605)
Biochem/physiol Actions
IL-17, initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.
IL-17A belongs to the IL-17 family and is produced by Th17 cells, a subset of T helper cells. Interleukin 17 (IL-17), initially known as CTLA-8, is a T cell expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis. IL-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines, upregulates production of growth factors that promote angiogenesis, and enhances expression of adhesion molecules in fibroblasts.
Initially known as CTLA-8; is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system; has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.
Physical form
Lyophilized from a 0.2 μm filtered solution of 10 mM Tris-HCl pH 7.4+ 250 mM NaCl
Preparation Note
HumanKine Interleukin-17A (IL-17A), expressed in human HEK 293 cells, is a glycosylated homodimer with an apparent molecular mass of 30-35 kDa due to glycosylation. Production in human 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
Analysis Note
The specific activity was determined by the dose-dependent induction of IL-6 secretion from NDHF adult fibroblasts.
Legal Information
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
wgk
WGK 3
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Shu Zhu et al.
The Journal of experimental medicine, 207(12), 2647-2662 (2010-11-17)
Interleukin 17 (IL-17) plays critical roles in the pathogenesis of various autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE). How the signals triggered by this powerful inflammatory cytokine are controlled to avoid abnormal inflammatory responses is not well understood. In this
H Xiong et al.
International endodontic journal, 48(6), 505-511 (2014-07-22)
To investigate IL-17 expression in human pulpitis and to study the effects of IL-17 on the secretion of the chemokines IL-6 and IL-8 and the related signalling pathways. Samples of human dental pulp tissue were obtained from healthy controls and
Michael Notaras et al.
Molecular psychiatry (2021-06-24)
It is widely accepted that narcotic use during pregnancy and specific environmental factors (e.g., maternal immune activation and chronic stress) may increase risk of neuropsychiatric illness in offspring. However, little progress has been made in defining human-specific in utero neurodevelopmental
Thomas Fabre et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 3925-3933 (2014-09-12)
Activation of hepatic stellate cells (HSCs) is a key event in the initiation of liver fibrosis, characterized by enhanced extracellular matrix production and altered degradation. Activation of HSCs can be modulated by cytokines produced by immune cells. Recent reports have
Kelly M Adams et al.
PloS one, 9(8), e103263-e103263 (2014-08-21)
The epithelium plays an active role in the response to inhaled pathogens in part by responding to signals from the immune system. Epithelial responses may include changes in chemokine expression, increased mucin production and antimicrobial peptide secretion, and changes in
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