H6041
Interferon α 2A human
HumanKine®, ≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyopholized powder, suitable for cell culture
Synonym(s):
α 2A Interferon, Human Interferon α 2A, IFN-α 2A
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.77
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
monomer 16 kDa (glycosylated)
Impurities:
≤1EU/mg
Product Name
Interferon α 2A human, IFN-α 2A, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
biological source
human
recombinant
expressed in HEK 293 cells
assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
≤0.4 ng/mL EC50
quality
endotoxin tested
mol wt
monomer 16 kDa (glycosylated)
packaging
glass bottle of 10 μg (in glass bottle)
manufacturer/tradename
HumanZyme
technique(s)
cell culture | mammalian: suitable
impurities
≤1EU/mg
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... IFNA2(3440)
General description
The IFNA2 (interferon alpha 2) gene is mapped to human chromosome 9p21.3. It is considered to be a prototypic type I IFN subtype. The encoded protein contains 165 amino acid. Ifna2 protein structure possesses five α-helices, linked by two disulfide bonds.
Application
Interferon α 2A human has been used to check its antiviral action against chikungunya virus. It has also been used as a control to check the antiviral cytokine induction of Korean red ginseng.
Biochem/physiol Actions
IFNA2 is a type 1 interferon which acts as the first line of defense, and offers protection against pathogenic invasion.
Interferon α 2A (IFN-α 2A) belongs to the type I interferon protein family and is produced by many cell types in response to viral infection. It has antiproliferative and antitumor activities, as well as induction of apoptosis and the inflammatory response. IFN-α 2A enhances the expression of MHC proteins by increasing the presentation of antigen peptides and activates cytotoxic T cells.
Physical form
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
Preparation Note
HumanKine IFN-α 2A, expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 16 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
Analysis Note
The activity is determined by the dose-dependent cytotoxicity of the human TF-1 cell line (human erythroleukemic indicator cell line)) ≤ 0.4.
Legal Information
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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IFNA2: The prototypic human alpha interferon
Paul F, et al.
Gene, 567(2), 132-137 (2015)
Evaluation of broad-spectrum antiviral compounds against chikungunya infection using a phenotypic screening strategy
Bonotto RM, et al.
F1000Research, 7 (2018)
Loss of tumor suppressive microRNA-31 enhances TRADD/NF-kappaB signaling in glioblastoma
Rajbhandari R, et al.
Testing, 6(19), 17805-17805 (2015)
A R Mire-Sluis et al.
Journal of immunological methods, 195(1-2), 55-61 (1996-09-09)
Interferons-alpha and -beta (IFN-alpha and -beta) are cytokines that are widely known to induce potent anti-viral activity. However, it has become increasingly apparent that IFN-alpha and -beta exert a variety of other biological effects, including anti-tumour and immunomodulatory activities and
Evaluation of broad-spectrum antiviral compounds against chikungunya infection using a phenotypic screening strategy
Bonotto RM, et al.
F1000Research, 7 (2018)
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