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Merck
CN

H0915

Sigma-Aldrich

Hydroxychloroquine sulfate

≥98% (HPLC), powder, anti-inflammatory

Synonym(s):

Hydroxychloroquine sulfate, 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate

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1 G
¥757.61
5 G
¥2,457.58
25 G
¥9,599.27

¥757.61


Available to ship on2025年4月24日Details


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1 G
¥757.61
5 G
¥2,457.58
25 G
¥9,599.27

About This Item

Empirical Formula (Hill Notation):
C18H26ClN3O · H2SO4
CAS Number:
Molecular Weight:
433.95
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

¥757.61


Available to ship on2025年4月24日Details


Request a Bulk Order

Product Name

Hydroxychloroquine sulfate, ≥98% (HPLC), powder

Quality Level

Assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to off-white

solubility

H2O: >20 mg/mL

SMILES string

OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12

InChI

1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)

InChI key

JCBIVZZPXRZKTI-UHFFFAOYSA-N

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This Item
29124U29127U29128U
fitting

thread for 11 mm

fitting

thread for 11 mm

fitting

thread for 11 mm

fitting

thread for 11 mm

feature

closure type crimp top vial

feature

closure type crimp top vial

feature

closure type crimp top vial

feature

closure type crimp top vial

volume

2 mL

volume

2 mL

volume

2 mL

volume

2 mL

material

PTFE/silicone/PTFE septum, clear glass vial, aluminum seal

material

PTFE/red rubber septum, aluminum seal, clear glass vial

material

PTFE/rubber septum, aluminum seal, amber glass vial

material

PTFE/silicone septum, aluminum seal, amber glass vial

compatibility

for use with Agilent/HP 1050/1090, 1100, 7673A (Series I, II), for use with Hitachi, for use with Shimadzu GC and LC Autosamplers, for use with Thermo Fisher HPLC Spectra, GC TRACE, AS3000, AI3000, AS3500, for use with Waters Alliance

compatibility

for use with Agilent/HP 1050/1090, 1100, 7673A (Series I, II), for use with CTC LC PAL, GC PAL, for use with Hitachi, for use with PerkinElmer Autosystem, Clarus 500, PE ISS-100, 200, Integral 4000, Series 200, for use with Shimadzu GC and LC Autosamplers, for use with Spark Marathon, MIdas, Triathlon, for use with Thermo Fisher HPLC Spectra, GC TRACE, AS3000, AI3000, AS3500, for use with Varian GC Autosamplers (8000, 8100, 8200, 8400, 8410), LC Autosamplers (9090, 9095, Marathon), for use with Waters Alliance

compatibility

for use with Agilent/HP 1050/1090, 1100, 7673A (Series I, II), for use with CTC LC PAL, GC PAL, for use with Hitachi, for use with PerkinElmer Autosystem, Clarus 500, PE ISS-100, 200, Integral 4000, Series 200, for use with Shimadzu GC and LC Autosamplers, for use with Spark Marathon, MIdas, Triathlon, for use with Thermo Fisher HPLC Spectra, GC TRACE, AS3000, AI3000, AS3500, for use with Varian GC Autosamplers (8000, 8100, 8200, 8400, 8410), LC Autosamplers (9090, 9095, Marathon), for use with Waters Alliance

compatibility

for use with Agilent/HP 1050/1090, 1100, 7673A (Series I, II), for use with CTC LC PAL, GC PAL, for use with Hitachi, for use with PerkinElmer Autosystem, Clarus 500, PE ISS-100, 200, Integral 4000, Series 200, for use with Shimadzu GC and LC Autosamplers, for use with Spark Marathon, MIdas, Triathlon, for use with Thermo Fisher HPLC Spectra, GC TRACE, AS3000, AI3000, AS3500, for use with Varian GC Autosamplers (8000, 8100, 8200, 8400, 8410), LC Autosamplers (9090, 9095, Marathon), for use with Waters Alliance

description

unassembled

description

unassembled

description

unassembled

description

unassembled

Application

Hydroxychloroquine sulfate has been used:
  • as an inhibitor of autophagy to treat cells for apoptosis assay[1] to study the role of pirarubicin induced autophagy in bladder cancer cell line[2]
  • to evaluate the antiviral mechanism of hydroxychloroquine against DENV-2 (dengue virus-2) infection by immunofluorescence assay[3]
  • to inhibit lysosome fusion with the autophagosome[4]

Biochem/physiol Actions

Hydroxychloroquine is also used for treating rheumatoid arthritis and systemic lupus erythematosus.[5]
Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor.
Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used in treating malaria.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Pharmacotherapeutics for Advanced Practice, 536, 435-435 (2006)
Barry Ladizinski et al.
Journal of the American Academy of Dermatology, 68(5), 749-755 (2013-02-05)
Frontal fibrosing alopecia (FFA) is a type of scarring hair loss primarily observed in postmenopausal women and characterized by fronto-tempero-parietal hairline recession, perifollicular erythema, and loss of eyebrows. The incidence is unknown, but the number of women presenting with this
Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of rapamycin signaling pathway in human bladder cancer cells
Li K, et al.
Biochemical and Biophysical Research Communications, 460(2), 380-385 (2015)
The autophagy inhibitor spautin-1, either alone or combined with doxorubicin, decreases cell survival and colony formation in canine appendicular osteosarcoma cells
Schott CR, et al.
Testing, 13(10), e0206427-e0206427 (2018)
Fluorescence Microscopy Analysis of Drug Effect on Autophagosome Formation
Stankov M, et al.
Antimicrobial agents and chemotherapy (2013)

Articles

We presents an article on Autophagy in Cancer Promotes Therapeutic Resistance

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