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G1002

Sigma-Aldrich

Gly-Gly

≥99% (titration)

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Synonym(s):
Diglycine, Glycyl-glycine
Linear Formula:
NH2CH2CONHCH2COOH
CAS Number:
556-50-3
Molecular Weight:
132.12
Beilstein:
1765223
EC Number:
209-127-8
MDL number:
MFCD00008130
UNSPSC Code:
12352209
PubChem Substance ID:
24895032
NACRES:
NA.26

Quality Level

400

Assay

≥99% (titration)

form

powder

color

white

useful pH range

7.5-8.9

pKa (25 °C)

8.2

mp

262-264 °C

application(s)

diagnostic assay manufacturing

SMILES string

NCC(=O)NCC(O)=O

InChI

1S/C4H8N2O3/c5-1-3(7)6-2-4(8)9/h1-2,5H2,(H,6,7)(H,8,9)

InChI key

YMAWOPBAYDPSLA-UHFFFAOYSA-N

Gene Information

human ... SLC15A1(6564)

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Application

Gly-Gly has been used as a buffer for the measurement of glucose-6-phosphate dehydrogenase (G6PDH) activity and as a component of luciferase assay buffer.

Biochem/physiol Actions

Gly-Gly or diglycine is the simplest dipeptide. It may possess proteolytic properties. Gly-gly is hydrolyzed by glycylglycine dipeptidase.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Primary Epithelial Cell Models for Cystic Fibrosis Research
Scott H. Randell
Methods in Molecular Biology null
Zheng Ma et al.
Antimicrobial agents and chemotherapy, 53(7), 2857-2864 (2009-04-22)
Nephrotoxicity is an important limitation to the clinical use of colistin against Pseudomonas aeruginosa and other gram-negative pathogens. Previous work reported net tubular reabsorption of colistin by the kidney in vivo, but there is no knowledge of its disposition within
P B Armentrout et al.
Journal of the American Society for Mass Spectrometry, 23(4), 632-643 (2011-09-29)
We present a full molecular description of fragmentation reactions of protonated diglycine (H(+)GG) by studying their collision-induced dissociation (CID) with Xe using a guided ion beam tandem mass spectrometer (GIBMS). Analysis of the kinetic energy-dependent CID cross sections provides the
Namrata D Udeshi et al.
Molecular & cellular proteomics : MCP, 12(3), 825-831 (2012-12-26)
Detection of endogenous ubiquitination sites by mass spectrometry has dramatically improved with the commercialization of anti-di-glycine remnant (K-ε-GG) antibodies. Here, we describe a number of improvements to the K-ε-GG enrichment workflow, including optimized antibody and peptide input requirements, antibody cross-linking
P B Armentrout et al.
Journal of the American Society for Mass Spectrometry, 23(4), 621-631 (2011-09-29)
We present a full computational description of the fragmentation reactions of protonated diglycine (H(+)GG). Relaxed potential energy surface scans performed at B3LYP/6-31 G(d) or B3LYP/6-311 + G(d,p) levels are used to map the reaction coordinate surfaces and identify the transition states (TSs) and
View All Related Papers

Protocols

Enzymatic Assay of Glucose-6-Phosphate Dehydrogenase (EC 1.1.1.49)

To measure glucose-6-phosphate dehydrogenase activity, beta-nicotinamide adenine dinucleotide phosphate is used in a spectrophotometric rate determination assay at 340 nm.

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