F5006
2-Fluoro-2-deoxy-D-glucose
glycosylation inhibitor, glucose analog
Synonym(s):
2-Deoxy-2-fluoro-D-glucose, FDG, 2-Deoxy-2-fluoro-D-glucose
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About This Item
Empirical Formula (Hill Notation):
C6H11FO5
CAS Number:
Molecular Weight:
182.15
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
Quality Level
assay
≥98.00% (TLC)
form
powder
mol wt
182.15 g/mol
concentration
≤100% (2-Fluoro-2-deoxy-D-glucose)
color
, white to white with yellow cast
mp
174-176 °C
solubility
water: 49.00-51.00 mg/mL, clear, colorless to faintly yellow
storage temp.
2-8°C
SMILES string
OCC1OC(O)C(F)C(O)C1O
InChI
1S/C6H11FO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1H2
InChI key
ZCXUVYAZINUVJD-UHFFFAOYSA-N
General description
2-Fluoro-2-deoxy-D-glucose is non-toxic and a structural analog of glucose, significantly inhibiting glycosylation. As a glucose analog, uptake of 2-Fluoro-2-deoxy-D-glucose is rapid in brain and heart cells.
2-Fluoro-2-deoxy-D-glucose can be taken up by cells but does not undergo metabolic glycolysis.
2-Fluoro-2-deoxy-D-glucose can be taken up by cells but does not undergo metabolic glycolysis.
Application
2-Fluoro-2-deoxy-D-glucose is used as a tracer for rapid tumor detection. It is used as a glucose analog to study glucose uptake in mice with radiation and burn injuries. Oncology therapy studies use FDG in combination with PET (Positron Emission Topography)
Biochem/physiol Actions
Glucose analog that inhibits cellular glycosylation.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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C J Hoekstra et al.
European journal of nuclear medicine, 27(6), 731-743 (2000-07-20)
[18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) is considered a valuable tool in the diagnosis and staging of cancer. In addition, it seems promising as a technique to monitor response to therapy. Progress is hampered, however, by the fact that various
Frank J Brooks et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(1), 37-42 (2013-11-23)
The number of studies in the literature involving quantification of the metabolic heterogeneity seen in (18)F-FDG PET images has increased sharply over recent years. We hypothesized that inclusion of very small regions of interest as unique data points will have
G J Bosman et al.
Biochimica et biophysica acta, 696(3), 285-289 (1982-03-29)
Tunicamycin, 2-deoxy-D-glucose and 2-deoxy-2-fluoro-D-glucose inhibit dimethyl sulfoxide-induced differentiation of Friend cells. This inhibition, characterized by inhibition of hemoglobin synthesis, is accompanied by a specific inhibition of protein glycosylation. The results of cloning experiments indicate that this inhibition specifically affects cells
Global Trade Item Number
| SKU | GTIN |
|---|---|
| F5006-25MG | 04061833618004 |
| F5006-100MG | 04061833617991 |