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  • Inhibitors of protein glycosylation inhibit the differentiation of Friend erythroleukemia cells.

Inhibitors of protein glycosylation inhibit the differentiation of Friend erythroleukemia cells.

Biochimica et biophysica acta (1982-03-29)
G J Bosman, P Boer, E P Steyn-Parvé
ABSTRACT

Tunicamycin, 2-deoxy-D-glucose and 2-deoxy-2-fluoro-D-glucose inhibit dimethyl sulfoxide-induced differentiation of Friend cells. This inhibition, characterized by inhibition of hemoglobin synthesis, is accompanied by a specific inhibition of protein glycosylation. The results of cloning experiments indicate that this inhibition specifically affects cells in the period preceding their commitment. These results suggest that glycoprotein synthesis is a requirement for Friend erythroleukemia cells in order to initiate the expression of the terminal differentiation program.

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Sigma-Aldrich
2-Fluoro-2-deoxy-D-glucose, glycosylation inhibitor, glucose analog