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Merck
CN

E5156

Epinastine hydrochloride

≥98% (HPLC), H1 histamine receptor antagonist, solid

Synonym(s):

9,13b-Dihydro-1H-dibenz[cf]imidazo[1,5-a]azepine hydrochloride, WAL-801Cl

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About This Item

Empirical Formula (Hill Notation):
C16H15N3 · HCl
CAS Number:
108929-04-0
Molecular Weight:
285.77
UNSPSC Code:
12352200
PubChem Substance ID:
24894608
NACRES:
NA.77
MDL number:
MFCD00933434

Key Documents

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Product Name

Epinastine hydrochloride, ≥98% (HPLC), solid

SMILES string

Cl[H].NC1=NCC2N1c3ccccc3Cc4ccccc24

InChI key

VKXSGUIOOQPGAF-UHFFFAOYSA-N

InChI

1S/C16H15N3.ClH/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16;/h1-8,15H,9-10H2,(H2,17,18);1H

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H2O: 38 mg/mL

originator

Boehringer Ingelheim

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... HRH1(3269)

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General description

Epinastine has antihistamine functions. In mast cells, it may modulate cytokine and chemokine production. In dendritic cells, it controls T helper cell mediated immune response. Epinastine hydrochloride does not traverse the brain barrier. Oral dosage of epinastine hydrochloride is prescribed for children with sleep-disordered breathing (SDB) and nasal inflammation. Ophthalmic solution of epinastine is effective for allergic conjunctivitis.

Biochem/physiol Actions

Epinastine hydrochloride is a non-sedating H1 histamine receptor antagonist.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000475790
0000475791
0000475791
0000475790
0000377982

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The Effectiveness of Epinastine Hydrochloride for Pediatric Sleep-Disordered Breathing Related Symptoms Caused By Hyperesthetic Non-Infectious Rhinitis
Hara H, et al.
Otolaryngology, 4(150), 2-2 (2013)
Population pharmacokinetics of epinastine, a histamine H1 receptor antagonist, in adults and children
Sarashina A, et al.
British Journal of Clinical Pharmacology, 59(1), 43-53 (2005)
Influence of epinastine hydrochloride, an H1-receptor antagonist, on the function of mite allergen-pulsed murine bone marrow-derived dendritic cells in vitro and in vivo
Oshima KZ, et al.
Mediators of Inflammation, 2009 (2009)
Inhibition of angiogenic factor production from murine mast cells by an antiallergic agent (epinastine hydrochloride) in vitro
Asano K, et al.
Mediators of Inflammation, 2008 (2008)
Yukihisa Matsumoto et al.
Neurobiology of learning and memory, 101, 103-113 (2013-02-06)
Sensory preconditioning (SPC) is a procedure to demonstrate learning to associate between relatively neutral sensory stimuli in the absence of an external reinforcing stimulus, the underlying neural mechanisms of which have remained obscure. We address basic questions about neural processes
View All Related Papers

Articles

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