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Merck
CN

E2011

cis-5,8,11,14,17-Eicosapentaenoic acid

from fish oil, ≥99% (GC), liquid, 5-Lipoxygenase inhibitor

Synonym(s):

EPA, Timnodonic acid

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About This Item

Linear Formula:
CH3(CH2CH=CH)5(CH2)3CO2H
CAS Number:
10417-94-4
Molecular Weight:
302.45
NACRES:
NA.77
PubChem Substance ID:
24894450
UNSPSC Code:
12352211
MDL number:
MFCD00065716
Beilstein/REAXYS Number:
1714433

Key Documents

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Product Name

cis-5,8,11,14,17-Eicosapentaenoic acid, ≥99%

InChI

1S/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-

SMILES string

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O

InChI key

JAZBEHYOTPTENJ-JLNKQSITSA-N

biological source

fish oil

assay

≥99%

form

liquid

refractive index

n20/D 1.4977 (lit.)

mp

−54-−53 °C (lit.)

solubility

methanol: 50 mg/mL, clear, colorless

density

0.943 g/mL at 25 °C (lit.)

storage temp.

−20°C

Quality Level

200

Gene Information

human ... ALOX5(240)
mouse ... ALOX5(11689), Pparg(19016)
rat ... ALOX5(25290)

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Application

cis-5,8,11,14,17-Eicosapentaenoic acid has been used:
  • to test pharmacologic effect on steatosis in hepatocytes
  • as an analytical standard in Raman spectra measurements to characterize human breast cancer samples
  • in lipid peroxidation assay in mouse embryonic fibroblasts and in pre-treatment of cells for cell viability studies

Biochem/physiol Actions

5-Lipoxygenase inhibitor; reduces thromboxane A2 production.
Eicosapentaenoic acid (EPA) is essential for healthy living and alleviates obesity. It decreases the triglyceride levels by modulating very-low-density lipoprotein(VLDL) levels.

General description

Eicosapentaenoic acid is a polyunsaturated fatty acid (PUFAs) and is synthesized from linolenic acid. It is distributed in phospholipid bilayers of the cell membrane, synaptic membranes of the brain and retina. It is obtained majorly from fish oil, seaweed, phytoplankton, and camelina. Being an Omega-3 fatty acid, it shows cis-trans conformations.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

200.1 °F - closed cup

flash_point_c

93.4 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
0000467845
0000467844
0000467844
0000467845
0000434556

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Che-Hsin Lee et al.
International journal of molecular sciences, 15(6), 10334-10349 (2014-06-12)
Recent studies have shown that free fatty acids are associated with chronic inflammation, which may be involved in vascular injury. The intake of eicosapentaenoic acid (EPA) can decrease cardiovascular disease risks, but the protective mechanisms of EPA on endothelial cells
Docosahexaenoic acid enhances methylmercury-induced endoplasmic reticulum stress and cell death and eicosapentaenoic acid potentially attenuates these effects in mouse embryonic fibroblasts
Takanezawa Y, et al.
Toxicology Letters, 306(15), 35-42 (2019)
Nutrition and traumatic brain injury: improving acute and subacute health outcomes in military personnel (2011)
omega-3 Fatty acids reverse lipotoxity through induction of autophagy in nonalcoholic fatty liver disease
Chen Y, et al.
Nutrition, 31(11-12), 1423-1429 (2015)
Effect of eicosapentaenoic acid and docosahexaenoic acid on myogenesis and mitochondrial biosynthesis during murine skeletal muscle cell differentiation
Hsueh TY, et al.
Frontiers in nutrition, 5, 15-15 (2018)
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