Anti-Daxx antibody produced in rabbit

Death domain associated protein (Daxx), also known as ETS associated protein 1 (EAP1), is an adaptor protein that binds to the death domain of Fas. Daxx is a 120 kDa protein with a nuclear localization signal sequence. It is highly acidic due to extended glutamic acid-rich domains. Daxx mRNA is extensively expressed in fetal and adult human and mouse tissues. Daxx has also been found in the nucleus where it localizes with the promyelocytic leukemia protein (PML), a gene of acute promyelocytic leukemia (APL).

Anti-Daxx specifically recognizes human Daxx (120 kDa).

Synthetic peptide corresponding to the C-terminus of human Daxx. This sequence is identical in mouse and monkey.

Anti-Daxx antibody is suitable for:

• western blot (1:4,000 using human acute lymphoma Jurkat whole cell extract)
• microarray
• the detection and localization of Daxx by immunoblotting

Anti-Daxx antibody produced in rabbit has been used to visualize hDaxx.

The death domain-associated protein (Daxx) is a protein that interacts with FAS and subsequently regulates cellular apoptosis. Daxx also interacts with H3.3 histone and α-thalassemia X-linked mental retardation protein (ATRX) to regulate chromatin deposition at telomeres. In addition, it also acts as a pro-apoptotic molecule that can specifically enhance Fas-induced apoptosis by activating the Jun N-terminal kinase (JNK) signaling pathway, through its interaction with the apoptosis signal-regulating kinase 1 (ASK1).

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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