Skip to Content
Merck
CN
All Photos(1)

Documents

Safety Information

D7571

Sigma-Aldrich

Dimaprit dihydrochloride

≥98% (NMR)

Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
Carbamimidothioic acid, 3-(dimethylamino)propyl ester, hydrochloride (1:2), Dimaprit-2HCl
Empirical Formula (Hill Notation):
C6H15N3S · 2HCl
CAS Number:
23256-33-9
Molecular Weight:
234.19
MDL number:
MFCD00069260
UNSPSC Code:
12352200
PubChem Substance ID:
329798854
NACRES:
NA.77

Quality Level

100

Assay

≥98% (NMR)

form

powder

color

white to off-white

solubility

H2O: ≥50 mg/mL

originator

Roche

storage temp.

−20°C

SMILES string

Cl.Cl.CN(C)CCCSC(N)=N

InChI

1S/C6H15N3S.2ClH/c1-9(2)4-3-5-10-6(7)8;;/h3-5H2,1-2H3,(H3,7,8);2*1H

InChI key

DFWCPLGXFMSUCW-UHFFFAOYSA-N

Biochem/physiol Actions

The histamine H2 receptor influences various cardiovascular responses, including vasodilation and cardiac rhythm, regulates gastric acid secretion, and also plays a role in the immune system by inhibiting antibody production, T cell proliferation and cytokine production. Histamine receptors are members of the GPCR family, and H2 mediates cell signaling via internalization and interaction with the GTPase dynamin.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Hamid Ghasemi et al.
Pharmacological reports : PR, 69(6), 1393-1401 (2017-11-18)
Histamine and opiate systems contribute to supraspinal processing of pain. In the present study, we investigated the effects of microinjection of histamine and agonists and antagonists of histamine H The thalamic ventral posterolateral nuclei were bilaterally implanted with two guide
Xiaowei Chen et al.
Cell stem cell, 21(6), 747-760 (2017-12-05)
Myeloid-biased hematopoietic stem cells (MB-HSCs) play critical roles in recovery from injury, but little is known about how they are regulated within the bone marrow niche. Here we describe an auto-/paracrine physiologic circuit that controls quiescence of MB-HSCs and hematopoietic progenitors
J Sethi et al.
Neuroscience, 217, 84-95 (2012-05-15)
Histamine acts centrally to increase energy expenditure and reduce body weight by mechanisms not fully understood. It has been suggested that in the obese state hypothalamic histamine signaling is altered. Previous studies have also shown that histamine acting in the
Binu Kundukad et al.
Biophysical journal, 99(6), 1906-1915 (2010-09-23)
The flow properties of DNA are important for understanding cell division and, indirectly, cancer therapy. DNA topology controlling enzymes such as topoisomerase II are thought to play an essential role. We report experiments showing how double-strand passage facilitated by topoisomerase II
J Kitanaka et al.
Neuroscience, 147(3), 765-777 (2007-06-16)
The administration of methamphetamine (METH, 10 mg/kg, i.p.) to male ICR mice induced stereotyped behavior consisting of nail and/or wood chip biting (86.0%), continuous sniffing (12.0%), head bobbing (1.1%), and circling (1.0%) during the observation period of 1 h. Pretreatment
View All Related Papers

Articles

Histamine Receptors

We offers many products related to histamine receptors for your research needs.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service