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D4268

N^G,N^G-Dimethylarginine dihydrochloride

Name: NG,NG-Dimethylarginine dihydrochloride
Brand: SIGMA

≥98% (TLC), powder, NOS inhibitor

Synonym(s):

asym-Dimethylarginine, ADMA

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₈N₄O₂ · 2HCl

CAS Number:

220805-22-1

Molecular Weight:

275.18

UNSPSC Code:

12352209

PubChem Substance ID:

24278027

NACRES:

NA.77

MDL number:

MFCD00270857

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

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Properties

Product Name

N^G,N^G-Dimethylarginine dihydrochloride,

assay

≥98% (TLC)

Quality Level

200

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

Cl[H].Cl[H].CN(C)C(=N)NCCC[C@H](N)C(O)=O

InChI

1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1

InChI key

SYLNVYJOPZWPJI-ILKKLZGPSA-N

Gene Information

human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

Description

General description

N^G,N^G-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF).

Application

N^G,N^G- Dimethylarginine dihydrochloride has been used:

to study its effects on cardiovascular activities in rostral ventrolateral medulla (RVLM) in rats
as a standard for measuring L-arginine and dimethylarginines
to study its effects on hepatic deterioration

Biochem/physiol Actions

Reversible inhibitor of nitric oxide synthetase in vivo and in vitro.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000544978

0000508579

0000507968

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Articles

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Evaluation of salivary and serum ADMA levels in patients with periodontal and cardiovascular disease as subclinical marker of cardiovascular risk.

Gaetano Isola et al.

Journal of periodontology (2020-01-09)

Asymmetric dimethylarginine (ADMA) plays a crucial role in endothelial function and maybe a link for the known interaction of periodontitis and coronary heart disease (CHD). In this pilot study, we compared the impact of gingival health, periodontitis (CP), CHD, or

The restorative effect of ascorbic acid on liver injury inducedby asymmetric dimethylarginine

Okuyucu A, et al.

Turkish Journal of Biology, 40(2), 452-461 (2016)

Serum Levels of Metabolites Produced by Intestinal Microbes and Lipid Moieties Independently Associated With Acute-on-Chronic Liver Failure and Death in Patients With Cirrhosis.

Jasmohan S Bajaj et al.

Gastroenterology, 159(5), 1715-1730 (2020-07-21)

Inpatients with cirrhosis have high rates of acute-on-chronic failure (ACLF) development and high mortality within 30 days of admission to the hospital. Better biomarkers are needed to predict these outcomes. We performed metabolomic analyses of serum samples from patients with

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Global Trade Item Number

SKU	GTIN
D4268-50MG	04061833564233
D4268-10MG	04061833564226