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D184

Sigma-Aldrich

Diethylamine NONOate sodium salt hydrate

≥97% (NMR), crystalline, nitrix oxide donor

Synonym(s):

1,1-Diethyl-2-hydroxy-2-nitroso-hydrazine sodium, 2-(N,N-Diethylamino)-diazenolate 2-oxide sodium salt hydrate, DEA NONOate sodium salt hydrate, Diethylamine/nitric oxide complex sodium salt hydrate

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About This Item

Linear Formula:
(CH3CH2)2N–N(N=O)O- Na+ xH2O
CAS Number:
1314960-89-8
Molecular Weight:
155.13 (anhydrous basis)
MDL number:
MFCD11045976
UNSPSC Code:
12352116
PubChem Substance ID:
24893276
NACRES:
NA.77

product name

Diethylamine NONOate sodium salt hydrate, ≥97% (NMR)

Quality Level

100

Assay

≥97% (NMR)

form

crystalline

storage condition

desiccated
protect from light

color

white

mp

45 °C (lit.)

solubility

H2O: >10 mg/mL
methanol: >25 mg/mL

shipped in

dry ice

storage temp.

−20°C

SMILES string

O.[Na+].CCN(CC)N([O-])N=O

InChI

1S/C4H10N3O2.Na.H2O/c1-3-6(4-2)7(9)5-8;;/h3-4H2,1-2H3;;1H2/q-1;+1;

InChI key

BVCZSYKIXSAMOT-UHFFFAOYSA-N

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Application

Diethylamine NONOate sodium salt hydrate has been used as a nitric oxide donor to evaluate endothelium-independent dilation. It has also been used to determine the level of nitric oxide in cell free systems.

Biochem/physiol Actions

Diethylamine NONOate is a complex of diethylamine with nitric oxide used to generate a controlled release of nitric oxide in solution.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Francesco Tamagnini et al.
The Journal of physiology, 591(16), 3963-3979 (2013-05-15)
Synaptic plasticity in perirhinal cortex is essential for recognition memory. Nitric oxide and endocannabinoids (eCBs), which are produced in the postsynaptic cell and act on the presynaptic terminal, are implicated in mechanisms of long-term potentiation (LTP) and long-term depression (LTD)
High dietary fructose does not exacerbate the detrimental consequences of high fat diet on basilar artery function
Toklu HZ, et al.
Journal of Physiology And Pharmacology, 67(2), 205-205 (2016)
The functional and structural changes in the basilar artery due to overpressure blast injury
Toklu HZ, et al.
Journal of Cerebral Blood Flow and Metabolism, 35(12), 1950-1956 (2015)
Nina Jeppesen Edin et al.
Journal of radiation research, 54(6), 1015-1028 (2013-05-21)
In this study, a mechanism in which low-dose hyper-radiosensitivity (HRS) is permanently removed, induced by low-dose-rate (LDR) (0.2-0.3 Gy/h for 1 h) but not by high-dose-rate priming (0.3 Gy at 40 Gy/h) was investigated. One HRS-negative cell line (NHIK 3025)
Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson?s Disease Etiopathology
Wilkaniec A, et al.
Molecular Neurobiology, 56(1), 125-140 (2019)
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