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D127

Sigma-Aldrich

Dextrorphan tartrate

powder

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Synonym(s):
(+)-3-Hydroxy-N-methylmorphinan (+)-tartrate salt, Dextrorphan D-tartrate
Empirical Formula (Hill Notation):
C17H23NO · C4H6O6
CAS Number:
143-98-6
Molecular Weight:
407.46
UNSPSC Code:
12352200
PubChem Substance ID:
24277974
NACRES:
NA.32

form

powder

color

white

solubility

H2O: >10 mg/mL

SMILES string

O[C@@H]([C@H](O)C(O)=O)C(O)=O.CN1CC[C@@]23CCCC[C@@H]2[C@@H]1Cc4ccc(O)cc34

InChI

1S/C17H23NO.C4H6O6/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17;5-1(3(7)8)2(6)4(9)10/h5-6,11,14,16,19H,2-4,7-10H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t14-,16+,17+;1-,2-/m10/s1

InChI key

RWTWIZDKEIWLKQ-FEBOIHDFSA-N

Gene Information

human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRINA(2907)

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Application

Dextrorphan tartrate has been used to study its effects on blood glucose levels by targeting pancreatic islets.

Biochem/physiol Actions

Dextrorphan is a noncompetitive NMDA glutamate receptor antagonist that attenuates glutamate neurotoxicity in cortical cell cultures.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

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A I Faden et al.
Science (New York, N.Y.), 244(4906), 798-800 (1989-05-19)
Brain injury induced by fluid percussion in rats caused a marked elevation in extracellular glutamate and aspartate adjacent to the trauma site. This increase in excitatory amino acids was related to the severity of the injury and was associated with
Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets
Okka S, et al.
Cell Chemical Biology (2021)

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