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D122

Sigma-Aldrich

Domperidone

powder, ≥98% (HPLC)

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Synonym(s):
4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine
Empirical Formula (Hill Notation):
C22H24ClN5O2
CAS Number:
57808-66-9
Molecular Weight:
425.91
EC Number:
260-968-7
MDL number:
MFCD00069256
UNSPSC Code:
12352200
PubChem Substance ID:
24277911
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: >10 mg/mL
0.1 M HCl: soluble
0.1 M NaOH: slightly soluble
H2O: insoluble

originator

Johnson & Johnson

SMILES string

Clc1ccc2N(C3CCN(CCCN4C(=O)Nc5ccccc45)CC3)C(=O)Nc2c1

InChI

1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)

InChI key

FGXWKSZFVQUSTL-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816) , KCNH2(3757)
rat ... Drd1a(24316) , Drd2(24318) , Drd3(29238) , Htr3a(79246)

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Related Categories

Biochem/physiol Actions

Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H361fd

Hazard Classifications

Repr. 2

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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S Lazareno et al.
European journal of pharmacology, 81(2), 273-285 (1982-07-09)
Specific binding of [3H]spiperone and [3H]domperidone, displaceable by 1 microM d-butaclamol, was examined in rat striatal membranes. Initial saturation and displacement experiments indicated that [3H]spiperone bound to more sites than [3H]domperidone and that, whilst all displacing drugs were more potent
Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity.
P M Laduron et al.
Biochemical pharmacology, 28(14), 2161-2165 (1979-07-15)
Domperidone.
M C Champion
General pharmacology, 19(4), 499-505 (1988-01-01)
R N Brogden et al.
Drugs, 24(5), 360-400 (1982-11-01)
Domperidone is a dopamine antagonist that does not readily enter the central nervous system. Given parenterally or orally it increases gastric emptying of liquids and increases lower oesophageal sphincter pressure in healthy subjects. The antiemetic and pharmacodynamic profile of domperidone
Savio C Reddymasu et al.
The American journal of gastroenterology, 102(9), 2036-2045 (2007-05-10)
Domperidone is a dopamine-2 receptor antagonist. It acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine. Unlike metoclopramide, it does not cause any adverse
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