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C5041

6-Carboxyfluorescein diacetate

Name: 6-Carboxyfluorescein diacetate
Brand: SIGMA

~95% purity (HPLC), powder

Synonym(s):

6-CFDA, 6-Carboxy-di-O-acetylfluorescein

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About This Item

Empirical Formula (Hill Notation):

C₂₅H₁₆O₉

CAS Number:

3348-03-6

Molecular Weight:

460.39

Beilstein:

67043

MDL number:

MFCD00036871

UNSPSC Code:

12171500

PubChem Substance ID:

24892748

NACRES:

NA.47

product name

6-Carboxyfluorescein diacetate, ≥95% (HPLC)

Quality Level

100
200

Assay

≥95% (HPLC)

form

powder

color

white to yellow

solubility

chloroform/ethanol (1:1): 9.80-10.20 mg/mL, clear, colorless to light yellow

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

−20°C

SMILES string

CC(=O)Oc1ccc2c(Oc3cc(OC(C)=O)ccc3C24OC(=O)c5ccc(cc45)C(O)=O)c1

InChI

1S/C25H16O9/c1-12(26)31-15-4-7-18-21(10-15)33-22-11-16(32-13(2)27)5-8-19(22)25(18)20-9-14(23(28)29)3-6-17(20)24(30)34-25/h3-11H,1-2H3,(H,28,29)

InChI key

QMOGCCYGOPYYNT-UHFFFAOYSA-N

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Hematology Stains

Histology Stains

Application

6-Carboxyfluorescein diacetate has been used to differentiate viable cells from apoptotic cells. Live cells that are not apoptotic accumulate 6-carboxyfluorescein but do not accumulate annexin.
Fluorescent wavelengths λex 492nm; λemm 517nm in 0.1M Tris, pH 8.0.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Visualization of hepatobiliary excretory function by intravital multiphoton microscopy.

Yuan Liu et al.

Journal of biomedical optics, 12(1), 014014-014014 (2007-03-09)

Intravital imaging of hepatobiliary excretion is vital for elucidating liver metabolism. In this work, we describe a novel method to observe the intravital dynamics of the uptake, processing, and excretion of an organic anion, 6-carboxyfluorescein diacetate (6-CFDA) in the hepatobiliary

Rapid enumeration of physiologically active bacteria in purified water used in the pharmaceutical manufacturing process.

M Kawai et al.

Journal of applied microbiology, 86(3), 496-504 (1999-04-10)

Physiologically active bacteria in purified water used in the manufacturing process of pharmaceutical products were enumerated in situ. Bacteria with growth potential were enumerated using the micro-colony technique and direct viable counting (DVC), followed by 24 h of incubation in

Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.

Yeli Gong et al.

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Increasing cell permeability of N-acetylglucosamine via 6-acetylation enhances capacity to suppress T-helper 1 (TH1)/TH17 responses and autoimmunity.

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PloS one, 14(3), e0214253-e0214253 (2019-03-27)

N-acetylglucosamine (GlcNAc) branching of Asn (N)-linked glycans inhibits pro-inflammatory T cell responses and models of autoimmune diseases such as Multiple Sclerosis (MS). Metabolism controls N-glycan branching in T cells by regulating de novo hexosamine pathway biosynthesis of UDP-GlcNAc, the donor

Small-molecule anticonvulsant agents with potent in vitro neuroprotection and favorable drug-like properties.

Garry R Smith et al.

Journal of molecular neuroscience : MN, 52(3), 446-458 (2013-11-28)

Severe seizure activity is associated with reoccurring cycles of excitotoxicity and oxidative stress that result in progressive neuronal damage and death. Intervention with these pathological processes is a compelling disease-modifying strategy for the treatment of seizure disorders. We have optimized

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