C2581
Anti-Cholecystokinin (26-33) (CCK-8) antibody produced in rabbit
whole antiserum
Synonym(s):
CCK Antibody - Anti-Cholecystokinin (26-33) (CCK-8) antibody produced in rabbit, Cck Antibody
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1 G
CN¥323.61
5 G
CN¥691.61
25 G
CN¥3,271.09
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1 G
CN¥323.61
5 G
CN¥691.61
25 G
CN¥3,271.09
About This Item
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![(Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide ≥97% (HPLC), powder](/deepweb/assets/sigmaaldrich/product/structures/125/021/32eb71ec-73e5-4cfc-94d0-ebcf5e784e39/640/32eb71ec-73e5-4cfc-94d0-ebcf5e784e39.png)
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
contains
15 mM sodium azide
species reactivity
human
packaging
antibody small pack of 25 μL
technique(s)
competitive inhibition ELISA: 1:1000-1:2000
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:8,000 using indirect immunoperoxidase staining of human stomach
1 of 4
This Item | CMC0001 | CMC0004 | CMC0007 |
|---|---|---|---|
| growth mode adherent or suspension | growth mode adherent or suspension | growth mode adherent or suspension | growth mode adherent or suspension |
| biological source Escherichia coli | biological source Escherichia coli | biological source Escherichia coli | biological source Escherichia coli |
| morphology rod shaped | morphology rod shaped | morphology rod shaped | morphology rod shaped |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
General description
Cholecystokinin (CCK) belongs to gastrointestinal hormone family is a neuropeptide hormone and neurotransmitter usually present in gastrointestinal (GI) tract and the central nervous system (CNS). CCK functions include enzyme secretion from pancreas, gall bladder contraction, intestinal motility; CCK will also inhibit gastrin induced acid secretion . This product is also useful for the study of mode of action, differential tissue expression and intracellular and subcellular localization of CCK in CNS and in neuroendocrine cells of digestive system. Anti-CCK-8 reacts specifically with sulfated CCK-8 and shows cross reactivity with unsulfated CCK-8 and Big Gastrin I.
Cholecystokinin (CCK) is a neuropeptide hormone and neurotransmitter widely distributed throughout the gastrointestinal (GI) tract and the central nervous system (CNS). CCK, Big Gastrin I, and vasoactive intestinal peptide (VIP) belong to the gastrin/cholcystokinin family. hormone family. CCK has a biologically active C-terminal pentapeptide. CCK exists as a larger precursor hormone, preproCCK (114 amino acids), from which several smaller fragments are derived, sharing a C-terminal tetrapeptide and a sulfated tyrosine residue. Sulfated CCK (26-33) amide (CCK-8) is the major and the most potent CCK form in the brain and periphery. CCK is widely distributed in several brain regions, including the cerebral cortex, hippocampus, amygdala nuclei, and the hypothalamus. In the periphery, CCK is localized mainly in nerve fibers in the myenteric and submucosal ganglia, as well as in endocrine cells of the gastrointestinal tract.
Immunogen
Synthetic sulfated CCK-8 conjugated to KLH.
Application
Anti-Cholecystokinin (26-33) (CCK-8) has been used in
- immunohistochemistry
- double-label immunofluorescence staining
- immunocytochemistry
- ELISA immunoassay
Anti-cholecystokinin (26-33) (CCK-8) antibody can be used to detect CCK peptide in pancreatic cancer cells by immunocytochemistry. It may also be used for ELISA immunoassay.
Anti-cholecystokinin (26-33) (CCK-8) antibody can be used to detect CCK peptide in pancreatic cancer cells by immunocytochemistry. It may also be used for dot blot immunoassay.
Biochem/physiol Actions
Cholecystokinin (CCK) stimulates enzyme secretion from the pancreas, gall bladder contraction, and intestinal motility and it inhibits gastrin-induced acid secretion. CCK may be involved in several physiological and behavioral functions such as satiety, anxiety, memory processes, and analgesia and in disorders such as panic disorder. In the central nervous system (CNS), CCK acts as a neurotransmitter and modulates the action of other neurotransmitters such as dopamine, 5-hydroxytryptamine (5-HT), γ-Aminobutyric acid (GABA) and excitatory amino acids. The multiple biological actions of CCK are mediated by two classes of receptors, the peripheral/brain CCK-A receptors and the brain CCK-B receptors.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Christine Feinle et al.
American journal of physiology. Gastrointestinal and liver physiology, 284(5), G798-G807 (2003-04-10)
The presence of nutrients in the small intestine slows gastric emptying and suppresses appetite and food intake; these effects are partly mediated by the release of gut hormones, including CCK. We investigated the hypothesis that the modulation of antropyloroduodenal motility
CCK in anxiety and cognitive processes
Dauge V and Lena I.
Neuroscience and Biobehavioral Reviews, 22(6), 815-825 (1998)
Characterization of the ?sporadically lurking HAP1-immunoreactive (SLH) cells? in the hippocampus, with special reference to the expression of steroid receptors, GABA, and progenitor cell markers
Islam M N, et al.
Neuroscience, 210(1), 67-81 (2012)
Effects of randomized whey-protein loads on energy intake, appetite, gastric emptying, and plasma gut-hormone concentrations in older men and women.
Caroline Giezenaar et al.
The American journal of clinical nutrition, 106(3), 865-877 (2017-07-28)
Phylogeny of the cholecystokinin/gastrin family
Johnsen A H
Frontiers in Neuroendocrinology, 19(2), 73-99 (1998)
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