C2211
Z-Leu-Leu-Leu-al
≥90% (HPLC)
Synonym(s):
MG-132
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About This Item
Empirical Formula (Hill Notation):
C26H41N3O5
CAS Number:
Molecular Weight:
475.62
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
MDL number:
Product Name
Z-Leu-Leu-Leu-al, ≥90% (HPLC)
Quality Level
assay
≥90% (HPLC)
form
powder
color
white
solubility
DMSO: soluble
storage temp.
−20°C
SMILES string
[H]C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1
InChI
1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
InChI key
TZYWCYJVHRLUCT-VABKMULXSA-N
Gene Information
human ... CTSB(1508), NFKB1(4790), PSMA1(5682)
Application
Z-Leu-Leu-Leu-al or MG132 has been used as a proteasome inhibitor. It has also been used to test the ubiquitylation and sumoylation pathways in urchin embryos.
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client*
Johannes W. Bigenzahn
Molecular and Cellular Proteomics (2016)
Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-? levels in brain
Benjamin W
Journal of Neurochemistry (2016)
MG132, a proteasome inhibitor, induced death of calf pulmonary artery endothelial cells via caspase-dependent apoptosis and GSH depletion.
Anticancer Research (2010)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C2211-5MG | 04061833475393 |