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Key Documents

Safety Information

C2211

Sigma-Aldrich

Z-Leu-Leu-Leu-al

≥90% (HPLC)

Synonym(s):

MG-132

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About This Item

Empirical Formula (Hill Notation):
C26H41N3O5
CAS Number:
Molecular Weight:
475.62
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32

Product Name

Z-Leu-Leu-Leu-al, ≥90% (HPLC)

Quality Level

Assay

≥90% (HPLC)

form

powder

color

white

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

[H]C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1

InChI

1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

InChI key

TZYWCYJVHRLUCT-VABKMULXSA-N

Gene Information

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Amino Acid Sequence

Z-Leu-Leu-Leu-al

Application

Z-Leu-Leu-Leu-al or MG132 has been used as a proteasome inhibitor. It has also been used to test the ubiquitylation and sumoylation pathways in urchin embryos.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How should Product C2211, Z-Leu-Leu-Leu-al, be dissolved?

    MG132 is soluble in DMSO or at 10 mg/mL in a chloroform:methanol solution (95:5). We test the solubility at 1 mg/mL in methanol.

  4. What is the solution stability of MG132, Product C2211, Z-Leu-Leu-Leu-al?

    This product can be stored in aliquots at -20°C for up to one month.

  5. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  6. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Vaino K. Hopsu-Havu, Mikko Jarvinen, Heidrun Kirschke
Proteolysis in Cell Functions (1997)
Proteasome inhibitors: from research tools to drug candidates
Alexei F.Kisselev
Chemistry and Biology, 8(8), 739-758 (2001)
MG132, a proteasome inhibitor, induced death of calf pulmonary artery endothelial cells via caspase-dependent apoptosis and GSH depletion.
Anticancer Research (2010)
Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-? levels in brain
Benjamin W
Journal of Neurochemistry (2016)
Differential Nanos 2 protein stability results in selective germ cell accumulation in the sea urchin
Nathalie Oulhen
Developmental Biology (2016)

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